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==Signalment==
==Signalment==
Large animals and horses are more susceptible to tetanus due to the ''C. tetani''
''Clostridium tetani'' generally cause infection via wound contamination. Cuts or deep puncture wounds are most commonly infected. ''C. tetani''produces tetanospasmin, a neurotoxin that inhibits the release of the neurotransmitters GABA and glycine from interneurons in the spinal cord and brain. This causes increased excitation of the brainstem and motor neurons, leading to unopposed muscle contraction.
''Clostridium tetani'' generally cause infection via wound contamination. Cuts or deep puncture wounds are most commonly infected. ''C. tetani''produces tetanospasmin, a neurotoxin that inhibits the release of the neurotransmitters GABA and glycine from interneurons in the spinal cord and brain. This causes increased excitation of the brainstem and motor neurons, leading to unopposed muscle contraction.