Changes

==Description==

==Description==

Tetanus is an infectious disease caused by the soil-inhabiting bacterium ''Clostridium tetani''.  

Tetanus is an infectious disease caused by the neurotoxin of the gram-positive bacterium ''Clostridium tetani''.  

==Signalment==

==Signalment==

Large animals and horses are more susceptible to tetanus due to the ''C. tetani''

Foals may also be affected via infection through the umbilicus.  

''Clostridium tetani'' generally cause infection via wound contamination. Cuts or deep puncture wounds are most commonly infected. ''C. tetani''produces tetanospasmin, a neurotoxin that inhibits the release of the neurotransmitters GABA and glycine from interneurons in the spinal cord and brain. This causes increased excitation of the brainstem and motor neurons, leading to unopposed muscle contraction.  

 

 

''Clostridium tetani'' generally causes infection via wound contamination and deposition of bacterial spores in tissue. Anaerobic conditions facilitate Cuts or deep puncture wounds are most commonly infected. ''C. tetani''produces tetanospasmin, a neurotoxin that inhibits the release of the neurotransmitters GABA and glycine from interneurons in the spinal cord and brain. This causes increased excitation of the brainstem and motor neurons, leading to unopposed muscle contraction.  

**  History

**  History

** Clinical signs

** Clinical signs

* Very rarely a wound where the bacteria may have entered may be seen.

* Very rarely a wound where the bacteria may have entered may be seen.