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| '''F. Hepatica'''
 
| '''F. Hepatica'''
 
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*can cause severe haemorrhagic [[Liver - Anatomy & Physiology|liver]] damage
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*death in heavy infestations in sheep during migratory phase (1 month) through the [[Liver - Anatomy & Physiology|liver]] tissue
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*recovered animals will have scarred [[Liver - Anatomy & Physiology|livers]]
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*more commonly associated with chronic bile duct inflammation - cholangitis [need link to below]
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**the adults live in the bile ducts
      
[[Image:Fasciola hepatica.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Adam Cuerden, Wikimedia Commons) ''']]
 
[[Image:Fasciola hepatica.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Adam Cuerden, Wikimedia Commons) ''']]
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===Acute Fascioliasis===
 
===Acute Fascioliasis===
The acute disease is a less common type of Fasciola hepatica, and generally occurs 2-6 weeks after large ingestion of metacercariae.  The young liver flukes migrate through the liver parenchyma causing severe haemorrhaging, due to the damage to the liver vasculature.
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The acute disease is a less common type of Fasciola hepatica, and generally occurs 2-6 weeks after large ingestion of metacercariae.  The young liver flukes migrate through the liver parenchyma causing severe haemorrhaging, due to the damage to the [[Liver - Anatomy & Physiology|liver]] vasculature.
Acute disease associated with immature fluke migration through the [[Liver - Anatomy & Physiology|liver]]  
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This occurs in late autumn and winter, mainly between the months of August to October.
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This occurs in late autumn and winter, mainly between the months of August to October. Outbreaks of acute fascioliasis usually present as sudden deaths.  On examination infected animals are weak, with pale mucous membranes.  They may also have enlarged livers, and the liver surface may be cover with a fibrinous peritonitis, particularly evident on the ventral lobe. Tracts become filled with blood and degenerate hepatocytes later infiltrated with [[Eosinophils|eosinophils]], [[Lymphocytes|lymphocytes]] and replaced by fibrosis.
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*severity of outbreaks depend on a number of epidemiological factors
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*the [[Liver - Anatomy & Physiology|liver]] of animals which die of this disease will be
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**enlarged
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**haemorrhagic
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**honeycombed with the tracts of migrating flukes
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***tracts become filled with blood and degenerate hepatocytes later infiltrated with [[Eosinophils|eosinophils]], [[Lymphocytes|lymphocytes]] and replaced by fibrosis
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**surface is covered with a fibrinous peritonitis, especially the ventral lobe
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**subcapsular haemorrhages are frequent
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**rupture into the abdomen is not an uncommon finding
      
[[Image:Fasciola hepatica - life cycle.jpg|300px|thumb|right|'''Fasciola hepatica life cycle(Copyright Centres for Disease Control and Prevention) ''']]
 
[[Image:Fasciola hepatica - life cycle.jpg|300px|thumb|right|'''Fasciola hepatica life cycle(Copyright Centres for Disease Control and Prevention) ''']]
'''Chronic Fascioliasis'''
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===Subactute Fascioliasis===
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This is caused by ingestion of metacercariae over a longer period of time.  Some may have migrated to the bile ducts, causing [[cholangitis]]
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===Chronic Fascioliasis===
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======Gross======
 
======Gross======
 
*[[Liver - Anatomy & Physiology|liver]] is reduced in size, unevenly
 
*[[Liver - Anatomy & Physiology|liver]] is reduced in size, unevenly
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