Changes

===Hepatic Jaundice===

===Hepatic Jaundice===

[[Liver - Anatomy & Physiology|Liver]] cell damage may lead to jaundice by two main mechanisms:

[[Liver - Anatomy & Physiology|Liver]] cell damage may lead to jaundice by two main mechanisms:

*In '''acute hepatic necrosis''', bile flow is obstructed by the degree of swelling of damaged cells, obstructing the flow of bile in the canaliculi.

*In '''acute hepatic necrosis''', damaged cells swell to such a degree that flow of bile in the canaliculi is obstructed.

*In '''chronic liver failure''', so much hepatic function is lost that the bilirubin produced by the constant turnover of red blood cells cannot be taken up and conjugated, leading to an accumulation of unconjugated bilirubin in the blood.  

*In '''chronic liver failure''', so much hepatic function is lost that the bilirubin produced by the constant turnover of red blood cells cannot be taken up and conjugated, leading to an accumulation of unconjugated bilirubin in the blood.