Changes

Feline Parvovirus kills the stem cells of the villi. The villi tip cells turnover normally but are not being replaced, leading to stunted villi and malabsorption.

Feline Parvovirus kills the stem cells of the villi. The villi tip cells turnover normally but are not being replaced, leading to stunted villi and malabsorption.

Clinical signs include pyrexia, severe enteritis (often bloody), dehydration, leukopenia, anemia

Clinical signs include pyrexia, severe enteritis (often bloody), dehydration, leukopenia, anemia.

Neonatal kittens less than 2 weeks show cerebellar hypoplasia

 

Neonatal kittens less than 2 weeks show cerebellar hypoplasia.  This leads to problems with coordination and balance.

 

The virus targets rapidly dividing cells: lymph nodes, bone marrow, crypts of small intestine. The breakdown of lymphoid tissue leads to a decreased white blood cell count, and destruction of lymphoid and myeloid stem cells.

 

*Virus targets rapidly dividing cells: lymph nodes, bone marrow, crypts of small intestine

====Epidemiology====

====Epidemiology====

*Infection by '''direct contact''' and '''fomites'''

Infection may be  via '''direct contact''' or by '''fomites'''. Subclinical infection may also occur.

*Subclinical infections occur

====Diagnosis====

====Diagnosis====

*Clinical signs

*Clinical signs

*Hematology: leukopenia

*Hematology: leukopenia

*Can be confirmed by haemagglutination (HA) or ELISA using feces

1. Analysis of faeces;  use of an '''Elisa''' to detect the virus antigen or detecting the virus DNA, using a '''PCR''' (Polymerase chain reaction.)

====Control====

====Control====

*'''Inactivated [[vaccines]]''' are available and essential for boarding

 

*Administered parenterally post-weaning to induce a systemic immune response to neutralize viremia

Modified live and inactivated virus vaccines are avaliable, with boosters every 1-2 years required.

One should also try to prevent exposure to kittens with feline panleukopenia.

==Parvovirus Enteritis==

==Parvovirus Enteritis==

 

Since a vaccine is available, this disease is now uncommon.

Over the last 10/15 years this has been seen primarily in the cat, but it is now also seen [[Canine Parvovirus|in the dog]].

* Since a vaccine is available, this disease is now uncommon.

* Over the last 10/15 years this has been seen primarily in the cat, but it is now also seen [[Canine Parvovirus|in the dog]].

===Clinical===

===Clinical===