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====Clinical Signs====
 
====Clinical Signs====
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The disease onset may be acute, peracute of chronic.  The insidious onset is most typical and with such cases, the clinical examination may reveal a bright, alert horse bright perhaps with some focal muscle atrophy.(Furr)In all cases, the clinical signs are referable to diffuse focal and  multifocal lesions of the white and grey matter of the spinal cord and brain (EPM3)
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Spinal cord:
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*Ataxia and paresis
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S neurona produces signs relating to diffuse, focal and multifocal lesions of the white and grey matter of the spinal cord and brain (EPM 3).
   
Ataxia or paresis of one or more limbs: stumbling, falling, knuckling and toe dragging.  
 
Ataxia or paresis of one or more limbs: stumbling, falling, knuckling and toe dragging.  
 
Sacrococcygeal involvement: mimics polyneuritis equi.  
 
Sacrococcygeal involvement: mimics polyneuritis equi.  
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Signs: asymmetrical weakness, ataxia, vestibular disease (peripheral or central) peripheral neuropathy, ill-defined hindlimb lameness, asymmetric muscle atrophy. (Vetstream)
 
Signs: asymmetrical weakness, ataxia, vestibular disease (peripheral or central) peripheral neuropathy, ill-defined hindlimb lameness, asymmetric muscle atrophy. (Vetstream)
Variable onset of disease:
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*Chronic - insidious in onset and difficult to diagnose.
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*Acute.
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*Peracute.
   
Spinal cord infection  :  
 
Spinal cord infection  :  
 
*Ataxia and weakness (hindlimbs > forelimbs) - often asymmetrical.  
 
*Ataxia and weakness (hindlimbs > forelimbs) - often asymmetrical.  
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Infection of cerebrum, basal nuclei, cerebellum:  
 
Infection of cerebrum, basal nuclei, cerebellum:  
 
Focal cerebral problems:  
 
Focal cerebral problems:  
*Seizures.
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*Seizures (may be the only clinical sign)(82 in Furr)
 
*Abnormal EEG.  
 
*Abnormal EEG.  
 
*Asymmetrical central blindness
 
*Asymmetrical central blindness
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