Changes

Animals with advanced '''stage 3''' will appear gaunt, and the meat is no longer deemed fit for human consumption.  Once the disease is present in the herd, it is ver difficult to get rid of it.

Animals with advanced '''stage 3''' will appear gaunt, and the meat is no longer deemed fit for human consumption.  Once the disease is present in the herd, it is ver difficult to get rid of it.

===Clinical===

==Clinical==

The infection primarily affects the intestine, and causes thickening of the mucosal wall. This causes impaired function, affecting its absorptive ability.  This may cause, severe emaciation, and chronic profuse diarrhoea.

The infection primarily affects the intestine, and causes thickening of the mucosal wall. This causes impaired function, affecting its absorptive ability.  This may cause, severe emaciation, and chronic profuse diarrhoea.

Death may result from: damage to the mucosa, not absorbing nutrients, or inflammatory loss of protein.

Death may result from: damage to the mucosa, not absorbing nutrients, or inflammatory loss of protein.

==Pathology==

==Gross Pathology==

 

===Gross===

The infected host appears emaciated.

The infected host appears emaciated.

Changes are milder in sheep and goats, than seen in cows, and is symptoms are often missed.

Changes are milder in sheep and goats, than seen in cows, and is symptoms are often missed.

===Histologically===

==Histologically==

There are many large macrophages (epithelioid macrophages) in mucosa, submucosa and lymph nodes.

There are many large macrophages (epithelioid macrophages) in mucosa, submucosa and lymph nodes.

2.  '''Multibacillary''': Many macrophages, many bacilli in macrophages, and few lymphocytes.

2.  '''Multibacillary''': Many macrophages, many bacilli in macrophages, and few lymphocytes.

===Diagnosis===

==Diagnosis==

Diagnosis is by; Histology, Serological tests, [[ELISA]] and AGID.

Diagnosis is by; Histology, Serological tests, [[ELISA]] and AGID.

[[Category:To_Do_-_Clinical]]

[[Category:To_Do_-_Clinical]]

[[Category:To_Do_-_Max]]

[[Category:To_Do_-_Max]]