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→Histamine 2 receptor antagonists
===Histamine 2 receptor antagonists===
===Histamine 2 receptor antagonists===
Parietal cells secrete HCl upon stimulation of histamine, acetylcholine or gastrin receptors.(EGUC) Competitive H2 receptor antagonists have successfully elevated gastric pH and treated gastric ulcers in mature horses and foals.(44,85,97 in Sachez)
Parietal cells secrete HCl upon stimulation of histamine, acetylcholine or gastrin receptors.(EGUC) Competitive H2 receptor antagonists have successfully elevated gastric pH and treated gastric ulcers in mature horses and foals.(44,85,97 in Sachez) There appears to be a great variability among horses in their dose requirements for H2 antagonists which may be explained by individual bioavilability for these compounds.(EGUC) Currently recommended doses proposed to be effective in the majority of horses(Sanchez) are:
Currently recommended doses proposed to be effective in the majority of horses(Sanchez) are:
*'''Cimetidine''' 20-30mg/kg PO every 8 hours or 6.6mg/kg IV every 6 hours
*'''Cimetidine''' 20-30mg/kg PO every 8 hours or 6.6mg/kg IV every 6 hours
*'''Ranitidine''' 6.6mg/kg PO every 8 hours or 1.5-2mg/kg IV every 6 hours
*'''Ranitidine''' 6.6mg/kg PO every 8 hours or 1.5-2mg/kg IV every 6 hours
*'''Famotidine''' 10-15mg/kg PO every 24 hours
*'''Famotidine''' 10-15mg/kg PO every 24 hours
===Proton-pump inhibitors===
===Proton-pump inhibitors===