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*Pulmonary form:
*Pulmonary form:
Small calcified or caseous nodules develop in the lungs, the surrounding lungs become inflammed and consolidated. The nodules may frequently degenerate to release their contents into the bronchioles which results in spread of the infection into the upper airways.
Small calcified or caseous nodules develop in the lungs, the surrounding lungs become inflamed and consolidated. The resulting pneumonia causes respiratory distress and coughing. The nodules frequently degenerate to release their contents into the bronchioles which results in spread of the infection into the upper airways.
*Nasal form:
*Nasal form:
Nodules form on the nasal mucosa, nasal septum and nasal turbinates. These break down to become ulcerative with raised irregular borders, the lesions may heal to form chracteristic star shaped scars. A thick mucopurulent discharge is seen at the nostrils. The local lymph nodes are enlarged and as the disease progresses, they become firm and adhere to underlyinig tissues.
Nodules form on the nasal mucosa, nasal septum and nasal turbinates. These break down to become ulcerative with raised irregular borders, the lesions may heal to form chracteristic star shaped scars. The local lymph nodes are enlarged and as the disease progresses, they become firm and adhere to underlyinig tissues.
* Cutaneous form:
* Cutaneous form:
====Chronic====
====Chronic====
* Nodular, ulcerative nasal lesions
* Nodular, ulcerative nasal lesions
* Subcutaneous nodules which rupure and discharge exudate
* Subcutaneous nodules which rupure and discharge exudate
*Pathogenesis:
*Pathogenesis:
**Presence of ''B. mallei'' in host causes hypersensitivity reaction
**Presence of ''B. mallei'' in host causes hypersensitivity reaction
**Chronic disease more common:
**Chronic disease more common:
***Cutaneous form (farcy): lymphangitis; nodules along lymphatic vesselsof limbs; ulcers develop and discharge pus
***Cutaneous form (farcy): lymphangitis; nodules along lymphatic vesselsof limbs; ulcers develop and discharge pus