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Gastric Ulceration - Dog (view source)

Revision as of 14:51, 3 August 2010

391 bytes removed ,  14:51, 3 August 2010
→‎Acid-base correction
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*If metabolic alkalosis: replace volume defecit with intravenous NaCl and KCl.  
 
*If metabolic alkalosis: replace volume defecit with intravenous NaCl and KCl.  
 
*Blocking of acid secretion:
 
*Blocking of acid secretion:
−
[[Gastroprotective Drugs#Histamine (H2) Receptor Antagonists|Histamine receptor antagonists]]include  
+
[[Gastroprotective Drugs#Histamine (H2) Receptor Antagonists|Histamine receptor antagonists]] include  
 
cimetidine, ranitidine and famotidine.
 
cimetidine, ranitidine and famotidine.
    
Omeprazole inhibits the hydrogen-potassium ATPase which prevents hydrogen ion production by the parietal cell. This is the drug of choice to treat ulceration associated with mass cell tumours and gastrinomas.
 
Omeprazole inhibits the hydrogen-potassium ATPase which prevents hydrogen ion production by the parietal cell. This is the drug of choice to treat ulceration associated with mass cell tumours and gastrinomas.
   −
**Gastrin antagonists:
+
−
***proglumide
  −
**Acetylcholine receptor antagonists:
  −
***atropine
  −
***pirenzepine
  −
**Adenyl cyclase inhibitors:
  −
***[[Gastroprotective Drugs#Prostaglandin E Analogues|prostaglangin E2 (PGE) analogues]] (misoprostol)
  −
**[[Gastroprotective Drugs#Proton Pump Inhibitors|H<sup>+</sup>:K<sup>+</sup>ATPase inhibitors ]]:- for use when patient is refractory to histamine antagonists
   
***omeprazole - good for exercise induced gastric ulceration
 
***omeprazole - good for exercise induced gastric ulceration
  
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