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Histopathology reveals centrilobular necrosis. Haematoxylin and eosin staining reveals basophilic intranuclear inclusion bodies in hepatocytes and macrophages.
 
Histopathology reveals centrilobular necrosis. Haematoxylin and eosin staining reveals basophilic intranuclear inclusion bodies in hepatocytes and macrophages.
 
It is possible to use immunofluorescence to stain for viral antigen in vascular endothelium.
 
It is possible to use immunofluorescence to stain for viral antigen in vascular endothelium.
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==Treatment==
 
==Treatment==
===Control===
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===Prevention===
 
In an outbreak
 
In an outbreak
 
*Isolate infected dogs
 
*Isolate infected dogs
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*Cross protection with CAV2
 
*Cross protection with CAV2
 
*Live vaccines are known to cause keratitis in Afghans, Red Setters and Saluki
 
*Live vaccines are known to cause keratitis in Afghans, Red Setters and Saluki
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==Prognosis==
 
==Prognosis==
  
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