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Fasciolosis (view source)

Revision as of 17:53, 5 August 2010

444 bytes removed ,  17:53, 5 August 2010
→‎Pathology
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===Pathology===
 
===Pathology===
 
In acute fasciolosis, immature flukes grow and migrate within the liver parenchyma, causing necrotic tracts and haemorrhage. Damage to hepatocytes releases GDH, accounting for the elevation detectable in serum levels. The liver is also subject to post-necrotic scarring, where necrotic areas shrink and fibrose and normal tissues hypertrophy.
 
In acute fasciolosis, immature flukes grow and migrate within the liver parenchyma, causing necrotic tracts and haemorrhage. Damage to hepatocytes releases GDH, accounting for the elevation detectable in serum levels. The liver is also subject to post-necrotic scarring, where necrotic areas shrink and fibrose and normal tissues hypertrophy.
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  −
e migrating flukes → liver
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  necrosis → anaerobic conditions → clostridial multiplication → toxin 
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production → disease
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The  acute disease  is a less common type of Fasciola hepatica, and generally  occurs 2-6  weeks after large ingestion of metacercariae.  The young  liver flukes  migrate through the liver parenchyma causing severe  haemorrhaging, due  to the damage to the [[Liver - Anatomy &  Physiology|liver]]  vasculature.
      
   
 
   
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