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| The toxoplasmosis patient does not usually require hospitalisation, unless they are suffering severe disease or cannot maintain adqequate nutrition or hydration unaided. Patients showing neurological signs should also be confined and monitored. | | The toxoplasmosis patient does not usually require hospitalisation, unless they are suffering severe disease or cannot maintain adqequate nutrition or hydration unaided. Patients showing neurological signs should also be confined and monitored. |
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− | Cats with suspected clinical toxoplasmosis should be
| + | Supportive care should be given to cats and dogs with clinical toxoplasmosis as required. The specific treatment for ''Toxoplasma gondii'' infection is clindamycin, at a dose of 12-25mg/kg per os every 12 hours. Treatment should generally be given for four weeks, but should continue for at least two weeks after clinical signs have disppeared. Side effects can include acute vomiting and diarrhoea, but stopping treatment for a day or so before reintroducing the drug usually resolves this. Alternatively, a trimethoprim-potentiated sulphonamide may be used at 15mg/kg orally, twice daily for 4 weeks. This is useful in animals where clindamycin is not tolerated or is ineffective in treating CNS toxoplasmosis. |
− | given supportive care, as required. Clindamycin
| + | |
− | hydrochloride, administered at 12 mg/kg orally every 12
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− | hours for four weeks, or a trimethoprim-sulphonamide | + | If trimethoprim-sulphonamide combinations |
− | combination, administered at 15 mg/kg orally every 12
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− | hours for four weeks, have been used most frequently by
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− | the author for the treatment of clinical feline toxoplasmosis.
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− | Administration of clindamycin for up to six weeks
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− | has been shown to be safe in research cats. In one study
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− | of cats given T gondii by carotid artery inoculation,
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− | some clindamycin-treated cats died while untreated cats
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− | did not (Davidson and others 1996). However, this was
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− | apparently related to the route of inoculation; cats infected
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− | by T gondii using the naturally occurring oral route
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− | did not have complications induced by clindamycin
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− | administration. Vomiting and small bowel diarrhoea
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− | occur in some cats on clindamycin therapy. These side
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− | effects usually develop acutely; if the drug is stopped for
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− | one to two days and then reinstituted, it is usually tolerated.
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− | Clindamycin has also been used successfully for
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− | the treatment of CNS toxoplasmosis in cats (Dubey and
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− | Lappin 1998). Some cats with CNS toxoplasmosis
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− | require continuous treatment.
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− | Cats that cannot tolerate clindamycin can be adminis-tered trimethoprim-sulphonamide combinations. Owing
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− | to good penetration into the CNS, trimethoprimsulphonamide
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− | therapy is also indicated for those cats
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− | with CNS toxoplasmosis which show a poor response to
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− | clindamycin. If trimethoprim-sulphonamide combinations
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| are used, a complete blood cell count should be | | are used, a complete blood cell count should be |
| performed every two weeks to monitor for the development | | performed every two weeks to monitor for the development |