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==Life Cycle==

==Life Cycle==

[[Image:Toxoplasmosis Life Cycle.jpg|Thumb|right|300px| Life cycle of ''Toxoplasma gondii''. Source: Wikimedia Commons; Author: LadyofHats (2010)]]

[[Image:Toxoplasmosis Life Cycle.jpg|thumb|right|300px| Life cycle of ''Toxoplasma gondii''. Source: Wikimedia Commons; Author: LadyofHats (2010)]]

In the naive definitive host, ''Toxoplasma gondii'' undergoes an enteroepithelial life cycle. Cats become infected by ingesting intermediate hosts containing tissue cysts, which release their bradyzoites in the gastrointestinal tract when the wall is digested. Bradyzoites then penetrate the small intestinal epithelium and produce five types of schizonts, which then give rise to merozoites. Male and female gamonts are formed from merozoites, which fertilise to form a macrogamont. A wall forms aroung the macrogamont to produce an oocyst, which is passed in the faeces approximately three days after ingestion of the tissue cyst. Initially, these oocysts are unsporulated and are therefore not infectious, but after 1 to 5 days sporulation occurs to produce two sporocysts, each with four infectious sporozoites. This sporulation is dependent on temperature and aeration, and sporocyts can remain viable in the environment for several months. As cats generally develop immunity to ''T. gondii'' after the initial infection, they will only shed oocysts once in their lifetime.

 

In naive cats, ''Toxoplasma gondii'' undergoes an enteroepithelial life cycle. Cats become infected by ingesting intermediate hosts containing tissue cysts, which release their bradyzoites in the gastrointestinal tract when the wall is digested. Bradyzoites then penetrate the small intestinal epithelium and produce five types of schizonts, which then give rise to merozoites. Male and female gamonts are formed from merozoites, which fertilise to form a macrogamont. A wall forms around the macrogamont to produce an oocyst, which is passed in the faeces approximately three days after ingestion of the tissue cyst. Initially, these oocysts are unsporulated and are therefore not infectious, but after 1 to 5 days sporulation occurs to produce two sporocysts, each with four infectious sporozoites. This sporulation is dependent on temperature and aeration, and sporocyts can remain viable in the environment for several months. As cats generally develop immunity to ''T. gondii'' after the initial infection, they will only shed oocysts once in their lifetime.

When other, non-feline, carnivores consume tissue cysts or oocysts from cat faeces, ''Toxoplasma gondii'' initiates extraintestinal replication. This process is the same for all hosts, and does not vary with the form of the parasite ingested. Bradyzoites and sporozoites, from cysts and oocysts respectively, are released in the intestine and infect the intestinal epithelium where they replicate. This produces tachyzoites, which are lunate in shape, about 6 microns in diameter and possess the ability to multiply in almost any cell type. The infected cell ruptures to release tachyzoites which then disseminate via blood and lymph to infect other tissues. Tachyzoites then replicate intracellularly and, if the cell does not burst, they eventually encyst and persist for the life of the host.

When other, non-feline, carnivores consume tissue cysts or oocysts from cat faeces, ''Toxoplasma gondii'' initiates extraintestinal replication. This process is the same for all hosts, and does not vary with the form of the parasite ingested. Bradyzoites and sporozoites, from cysts and oocysts respectively, are released in the intestine and infect the intestinal epithelium where they replicate. This produces tachyzoites, which are lunate in shape, about 6 microns in diameter and possess the ability to multiply in almost any cell type. The infected cell ruptures to release tachyzoites which then disseminate via blood and lymph to infect other tissues. Tachyzoites then replicate intracellularly and, if the cell does not burst, they eventually encyst and persist for the life of the host.