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Bovine Viral Diarrhoea Virus (view source)

Revision as of 12:44, 24 August 2010

719 bytes removed ,  12:44, 24 August 2010
→‎Pathology
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[[Image:BVD-MD.gif|right|thumb|125px|<small><center>Small erosions of MDV/BVDV - vesicles are microscopic (Courtesy of Alun Williams (RVC))</center></small>]]
 
[[Image:BVD-MD.gif|right|thumb|125px|<small><center>Small erosions of MDV/BVDV - vesicles are microscopic (Courtesy of Alun Williams (RVC))</center></small>]]
 
[[Image:Bvd2.gif|right|thumb|125px|<small><center>Coalescing lesions of BVDV (Courtesy of Alun Williams (RVC))</center></small>]]
 
[[Image:Bvd2.gif|right|thumb|125px|<small><center>Coalescing lesions of BVDV (Courtesy of Alun Williams (RVC))</center></small>]]
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*'''Mucosal Disease''': erosive condition produces small multiple, cleanly punched out lesion in mouth
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*[[Neutrophils|Neutrophils]] invade the ulcer and if bacterial colonisation occurs, further excavation follows. Either:
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::#This lesion develops a granular base and becomes diphtheritic.
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::#If bacterial colonisation does not take place, healing occurs within fourteen days.
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*Seen in most parts of mouth (or maybe on muzzle) e.g. dental pad, [[Cheeks - Anatomy & Physiology|cheeks]], sides of [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]]
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*Lesions extend throughout gut with particularly big ulcers in small intestine over [[Peyer's Patches - Anatomy & Physiology|Peyers patches]]. Necrosis occurs in lymph nodes and [[Spleen - Anatomy & Physiology|spleen]]
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*No vesicular stage, prickle cells die off from surface resulting in layer of necrotic debris over epithelial layer
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*Infection penetrates inward through stratum germinativum.
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*Epithelium does not recover as animal does not recover
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Mucosal disease
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At necropsy, erosions and ulcerations may be found throughout the GI tract. The mucosa over Peyer’s patches may be hemorrhagic and necrotic. Extensive necrosis of lymphoid tissues, especially gut-associated lymphoid tissue, is seen on microscopic examination.  
 
Lesions of the abomasum and small intestine are seen on post-mortem examination, and congestion of the large intestine mucosa results in a stripy, thickened appearance (Brownlie, 1985).
 
Lesions of the abomasum and small intestine are seen on post-mortem examination, and congestion of the large intestine mucosa results in a stripy, thickened appearance (Brownlie, 1985).
  
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