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→Side Effects and Contraindications
Most adverse effects and side effects are the same as those listed for phenobarbital; however, primidone administration may be associated with a higher incidence of hepatotoxicity. Hepatic necrosis, fibrosis and cirrhosis have been associated with chronic use of primidone. Intrahepatic cholestasis has occured in dogs in which primisone was combined with phenytoin.
Most adverse effects and side effects are the same as those listed for phenobarbital; however, primidone administration may be associated with a higher incidence of hepatotoxicity. Hepatic necrosis, fibrosis and cirrhosis have been associated with chronic use of primidone. Intrahepatic cholestasis has occured in dogs in which primisone was combined with phenytoin.
manufacturers do nor recommed its used in cats; in fact it is stated on the package inerst that its use should be cautioned in cats. However, studies in cats have demonstrated that primidone is probably safe.
manufacturers do nor recommed its used in cats; in fact it is stated on the package inerst that its use should be cautioned in cats. However, studies in cats have demonstrated that primidone is probably safe.
identical sedative side effects are seen in the dog after treatment with phenobarbital and after treatment with primidone. Primidone will cause all of the side effects noted for phenobarbital. primidone may induce nystagmus, nausea, drowsiness and ataxia. PD is more common in dogs treated with primisone. In man, megaloblastic anaemia is a side effect of primidone. In the dog, primidone induces progressive hepatic injury as manifested by increases in liver enzyme values. In a clinica study, signs of lover toxicity were repoerted in 14 of 20 dofs. Hepatic cirrhosis associated wth primidone and phenobarbital after 7 years of use has been reported in a dog. Dermatitis is a rarely reported side effect.
Should not be used with chloramphenicol - potent inhibotr of the microsomal enzyme system: sever CNS deression and inappetance.
==References==
==References==