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==Actions==
==Actions==
Neutrophils are the first inflammatory cells to enter damaged tissue from the blood after tissue damage has being caused. They are the predominant cell at 4 - 6 hours after the beginning of the inflammatory reaction, at 12 hours there are also substantial numbers of [[Macrophages|macrophages]] and at 24 hours there are as many neutrophils as [[Macrophages|macrophages]].
Neutrophils are the first inflammatory cells to enter damaged tissue from the blood after tissue damage has being caused. They are the predominant cell 4 - 6 hours after the beginning of an inflammatory reaction; at 12 hours there are also substantial numbers of [[Macrophages|macrophages]] and at 24 hours there are equal numbers of neutrophils and macrophages.
===Phagocytosis===
===Phagocytosis===
<p>The main role of the neutrophil is to engulf and destroy foreign material. They uptake this material via endocytosis and this surrounds the material in the neutrophil membrane forming a phagosome. Lysosomes inside the neutrophil then fuse with the phagosome and release their contents degrading the foreign material. Phagocytosing material shortens the lifespan of the neutrophil due to the build up of toxins both from the degraded bacteria etc. and also from its own lysosomes contents. Most neutrophils die after phagocytosing 5-25 bacteria and the dead neutrophils form [[Necrosis - Pathology#Pus Formation|pus]].</p>
<p>The main role of the neutrophil is to engulf and destroy foreign material. They uptake this material via endocytosis and this surrounds the material in the neutrophil membrane forming a phagosome. Lysosomes inside the neutrophil then fuse with the phagosome and release their contents degrading the foreign material. Phagocytosing material shortens the lifespan of the neutrophil due to the build up of toxins both from the degraded bacteria etc. and also from its own lysosomes contents. Most neutrophils die after phagocytosing 5-25 bacteria and the dead neutrophils form [[Necrosis - Pathology#Pus Formation|pus]].</p>