Changes

==TH₂ Cells==

==TH₂ Cells==

[[Image:TH2-Bcell.jpg|thumb|right|150px|TH2 cells incite increased antibody production - B. Catchpole, RVC 2008]]

[[Image:TH2-Bcell.jpg|thumb|right|200px|TH2 cells incite increased antibody production - B. Catchpole, RVC 2008]]

*TH2 cells help [[Lymphocytes#B cells|B cell]] produce antibody (''organism in tissue fluid'')

TH2 cells help [[B cells]] produce antibody where the organism in present in tissue fluid. The TH2 population influences B cell activation, proliferation and immunoglobulin production. TH2 T cells also secrete a range of cytokines:

* The TH2 population influences [[Lymphocytes#B cells|B cell]] activation, proliferation and immunoglobulin production.

#'''IL-4''' which stimulates B cell growth and induces the heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]], as well as proliferation of basophils and mast cells. IL-4 can inhibit some T cell responses.

* The TH2 [[Lymphocytes#T cells|T cell]] population secrete a range of cytokines.

#'''IL-5''' which activates B cells and stimulates a high rate of proliferation. IL-5 also promotes immunoglobulin synthesis and the proliferation and differentiation of eosinophils.

** '''IL-4'''

#'''IL-6''' also activates B cells, stimulates a high rate of proliferation and promotes immunoglobulin synthesis.

*** Stimulates [[Lymphocytes#B cells|B cell]] growth.

*** Gives heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]].

*** Proliferation of basophils/ mast cells.  

*** Can inhibit some [[T cells|T cell]] responses.

** '''IL-5'''

*** Activates [[B cells|B cells]].

*** Stimulates high rate [[B cells|B cells]] proliferation.  

*** Promotes immunoglobulin synthesis.

*** Proliferation and differentiation of eosinophils.

** '''IL-6'''  

*** Activates [[B cells|B cells]].

*** Stimulates high rate [[B cells|B cell]] proliferation.

*** Promotes immunoglobulin synthesis.

==Common Functions of Th₁ and TH₂ Cells==

==Common Functions of Th₁ and TH₂ Cells==