Changes

===TCR Complex===

===TCR Complex===

[[Image:TCR Complex.jpg|thumb|right|150px|TCR Complex - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

[[Image:TCR Complex.jpg|thumb|right|250px|TCR Complex - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

*The TCR is always associated with CD3  

The T cell Receptor, or TCR is always associated with CD3 which is referred to as the '''TCR complex'''. TCR is expressed on the surface of T cells in a noncovalent association with a complex of transmembrane polypeptides.

**The TCR and CD3 molecule is referred to as the '''TCR complex'''  

 

*TCR is expressed on the surface of T cells in noncovalent association with a complex of transmembrane polypeptides

CD3 contains 3 distinct polypeptide chains that are expressed exclusively on T cells: γ, ε, and δ. These molecules are members of the Ig superfamily - the ε chain associates with both γ and δ - and they play a 'chaperone' role in transporting newly synthesized TCR molecules to the cell surface.

*CD3 contains 3 distinct polypeptide chains:

CD3 also contains 2 identical chains: ζ and 16 kDa, which are found on T cells, macrophages and NK cells. Mice also can have an ε (eta) form.

**γ, ε, and δ  

**Members of the Ig superfamily

**The ε chain associates with both γ and δ

**'''chaperone''' role in transporting newly synthesized TCR molecules to the cell surface

*CD3 also contains 2 identical chains:

**ζ

**16 kDa

**Found on T cells, macrophages and NK cells

**Mice also can have an ε (eta) form

===Response to Activation===

===Response to Activation===