5,582
edits
Changes
B cell differentiation (view source)
Revision as of 15:47, 27 September 2010
, 15:47, 27 September 2010→T-Cell Dependent Response
Line 32:
Line 32:
*Response to '''protinaceous antigens'''+*Needs T cell help to respond appropriately+
−*Response occurs in germinal centres of follicles in secondary lymphoid tissues+*B cells act as antigen presenting cells on [[Major Histocompatability Complexes#Structure and Function Of MHC Class II|MHC II]]+*T cells interact via cell surface receptors with B cells+**CD40L on the T cell+**CD40 on the B cell
−*T cells produce [[Cytokines|'''cytokines''']]
−**E.g. IL-4
−*[[Immunoglobulins#Immunoglobulin Class Switching|Class switching]] occurs from IgM
−*Memory B cells are formed
===T-Cell Dependent Response===
===T-Cell Dependent Response===
[[Image:T cell Dependent Response Diagram.jpg|thumb|right|200px|Diagram showing the T cell dependent response (primary and secondary phases) - Copyright nabrown RVC]]
[[Image:T cell Dependent Response Diagram.jpg|thumb|right|200px|Diagram showing the T cell dependent response (primary and secondary phases) - Copyright nabrown RVC]]
−The B cell response is to '''protinaceous antigens''' and T cells moderate the response, which occurs in the germinal centres of follicles in secondary lymphoid tissues.
−B cells then act as antigen presenting cells on [[Major Histocompatability Complexes#Structure and Function Of MHC Class II|MHC II]], with T cells interacting via cell surface receptors:
−*CD40L on the T cell
−*CD40 on the B cell
−T cells produce [[Cytokines|'''cytokines''']] such as IL-4 which induces [[Immunoglobulins#Immunoglobulin Class Switching|class switching]] from IgM and the formation of memory cells.
−====Primary T Cell Dependent Response====
====Primary T Cell Dependent Response====
Line 74:
Line 69:
* The level of [[Immunoglobulin M|IgM]] antibody production is similar to the primary response
* The level of [[Immunoglobulin M|IgM]] antibody production is similar to the primary response
* The increase in antibody production occurs with [[Immunoglobulin G|IgG]]
* The increase in antibody production occurs with [[Immunoglobulin G|IgG]]
−===Plasma Cell Pathology===
===Plasma Cell Pathology===