Changes

<Br clear="left">

<Br clear="left">

===[[Neutrophils|Neutrophils]]===

==Neutrophils==

Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-G]].

Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-G]].

====Stages====

===Stages===

=====Myeloblast=====

====Myeloblast====

Large cell with a large nucleus and stains basophilic. Same stage exists for all granulocytes.

Large cell with a large nucleus and stains basophilic. Same stage exists for all granulocytes.

=====Promyelocyte=====

====Promyelocyte====

During this stage primary (azurophilic) granules are formed. Same stage exists for all granulocytes.

During this stage primary (azurophilic) granules are formed. Same stage exists for all granulocytes.

=====Neutrophilic myelocyte=====

====Neutrophilic myelocyte====

Developing neutrophil can now be differentiated from basophils and eosinophils as specific granules are now being formed.

Developing neutrophil can now be differentiated from basophils and eosinophils as specific granules are now being formed.

=====Neutrophilic metamyelocyte=====

====Neutrophilic metamyelocyte====

At this stage mitosis can no longer occur. The nucleus elongates, becomes heterochromatic and has a kidney like shape. Differentiation is now much clearer between other granulocytes as the specific granules are in a far greater number than the primary granules formed in the promyelocyte stage.

At this stage mitosis can no longer occur. The nucleus elongates, becomes heterochromatic and has a kidney like shape. Differentiation is now much clearer between other granulocytes as the specific granules are in a far greater number than the primary granules formed in the promyelocyte stage.

 

====Band cell====

=====Band cell=====

Nucleus elongates further and represents a horse shoe. Nucleus starts to segment.

Nucleus elongates further and represents a horse shoe. Nucleus starts to segment.

=====Neutrophil=====

====Neutrophil====

Mature neutrophil is formed and the nucleus is segmented and has 3 to 5 lobes. This lobular structure of the nucleus gives rise to the name polymorphonuclear neutrophil.

Mature neutrophil is formed and the nucleus is segmented and has 3 to 5 lobes. This lobular structure of the nucleus gives rise to the name polymorphonuclear neutrophil.

<br>

<br>

===[[Basophils|Basophils]]===

===[[Basophils|Basophils]]===

Under the stimulation of GM-CSF and Il-3 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-Ba]].

Under the stimulation of GM-CSF and Il-3 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-Ba]].