Changes

==Monocytes==

==Monocytes==

[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.

Monocytes develop from the same precursor as neutrophils - the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.

===Stages:===

===Stages:===

====Monoblast====

====Monoblast====

First stage after cell has differentiated into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]].

This is the first stage after cell has differentiated into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]].

====Promonocyte====

====Promonocyte====

Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).

Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing, which acts as a reservoir.

====Monocyte====

====Monocyte====

Monocytes are incapable of mitosis and enter circulation. They have a large kidney shaped nucleus with a slightly basophilic cytoplasm.

Monocytes are incapable of mitosis and enter the circulation. They have a large kidney shaped nucleus with a slightly basophilic cytoplasm, which is often vaculoated.

====Macrophage====

====Macrophage====

Once the monocyte has entered tissue it differentiates into a [[Macrophages|macrophage]].

Once the monocyte has entered tissue it differentiates into a [[Macrophages|macrophage]].

===Dendritic cells===

===Dendritic cells===

Develop from the monoblast under the stimualtion of GM-CSF and IL-4 into an immature dendritic cell. This then develops into the mature dendritic cell under stimulation of TNF-α.

These develop from the monoblast under the stimualtion of GM-CSF and IL-4 into an immature dendritic cell. This then develops into the mature dendritic cell under stimulation of TNF-α.

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