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*Free thrombin negative feedback - high levels of free thrombin destroys activated Factor VIII.
 
*Free thrombin negative feedback - high levels of free thrombin destroys activated Factor VIII.
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===Increased Coagulation - haemorrhagic shock syndrome==
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===Increased Coagulation - haemorrhagic shock syndrome===
 
Coagulants enhance the clotting process - the most commonly encountered coagulants are toxins such as snake venoms. Some venoms have a thrombin-like activity whereas other venoms have a plasma thromboplastin-like effect. Some snakes (Russell's viper, Malayan Pit viper) induce defibrination.  
 
Coagulants enhance the clotting process - the most commonly encountered coagulants are toxins such as snake venoms. Some venoms have a thrombin-like activity whereas other venoms have a plasma thromboplastin-like effect. Some snakes (Russell's viper, Malayan Pit viper) induce defibrination.  
  
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