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Coagulation Factor Deficiency (view source)
Revision as of 10:59, 29 September 2010
, 10:59, 29 September 2010no edit summary
==Introduction==
Factor deficiencies are often the result of congenital deficiency in one or more of the coagulation factors. Deficiencies lead to ineffective blood clotting and development of a disease syndrome characterized by excessive bleeding - deficiencies are often detected following trauma or surgery. Cccasionally bleeding may be spontaneous (e.g. into alimentary or urinary tracts). Deficiencies are often seen as familial inherited problems. Haemophilia (factor VIII deficiency) is probably the best understood condition.
==Von Willebrand's Disease==
This condition is seen in the dog, most frequently in Scottish Terriers and Chesapeake Bay Retrievers. It has become more prevalent recently in Dobermanns, Setters and German Shepherd dogs. A similar disease has been recorded in the pig.
Von Willebrand's Disease is an inherited autosomal recessive trait. It is incompletely dominant, so there is variable expression.
===Presentation===
* Purpura.
* Prolonged bleeding time.
* Reduced platelet adhesiveness.
* Low Factor XIII levels.
* The disease can be assessed by the measurement of Von Willebrand Factor protein levels.
* The disease can be assessed by the measurement of Von Willebrand Factor protein levels.
** A Factor VIII-related protein.
** A Factor VIII-related protein.