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Coagulation Factor Deficiency (view source)
Revision as of 20:09, 29 September 2010
, 20:09, 29 September 2010→Factor VIII
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* Factor VIII is known as antihaemophilic factor (AHF).+* Deficiency of this factor causes '''haemophilia A'''.
−** The primary thrombocyte plug is abnormal.
−*** More vascular channels than usual.
−*** Less fibrin-collagen contact around the edges.
−** Plugs are therefore easily dislodged.
−*** Results in rebleeding.
−*** Secondary plugs only form with difficulty.
−* Haemophilia is reported in horses and in around 20 breeds of dogs.
−* Haemophilia is as a sex-linked recessive condition.
−** Associated with the X chromosome.
−** Affects males only.
−* The severity of the disease correlates with the Factor VIII levels.
−* Haematomas and haemarthrosis are common lesions.
==Factor VIII ==
==Factor VIII ==
+Factor VIII is known as antihaemophilic factor (AHF); a deficiency of this factor causes 'haemophilia A'. In haemophilic conditions:
+*The primary thrombocyte plug is abnormal with more vascular channels than usual and less fibrin-collagen contact around the edges.
+*Plugs are therefore easily dislodged which results in rebleeding.
+*Secondary plugs only form with difficulty.
+Haemophilia is reported in horses and in around 20 breeds of dogs - it is known to be a sex-linked recessive condition associated with the X chromosome which affects only males.
−The severity of the disease correlates with the Factor VIII levels. Haematomas and haemarthrosis are common lesions.
−==Factor IX ==
==Factor IX ==