5,582
edits
Changes
Jump to navigation
Jump to search
no edit summary
Anticoagulant rodenticide toxiticy is one of the most common causes of acquired coagulopathy in small animals. Warfarin itself has a short half-life and a fairly low toxicity in non-rodent species, so unless large or repeated doses are consumed clinical bleeding is rare. However, the second generation anticoagulant rodenticides are far more potent, and it is possible for a domestic animal to acquire secondary poisoning by ingesting a killed rodent<sup>1</sup>. Dogs are most commonly effected, but predator species such as cats and owls do occaionally suffer from secondary poisonings.
Anticoagulant rodenticide toxiticy is one of the most common causes of acquired coagulopathy in small animals. Warfarin itself has a short half-life and a fairly low toxicity in non-rodent species, so unless large or repeated doses are consumed clinical bleeding is rare. However, the second generation anticoagulant rodenticides are far more potent, and it is possible for a domestic animal to acquire secondary poisoning by ingesting a killed rodent<sup>1</sup>. Dogs are most commonly effected, but predator species such as cats and owls do occaionally suffer from secondary poisonings.
The clotting factors - factor VII, factor XI and factors II and X in the extrinsic, intrinsic and common pathways respectively are dependent on Vitamn K when activated by the coagulation cascade.
==References==
==References==
Also see [[Anticoagulant Rodenticide Toxicity]]
Also see [[Anticoagulant Rodenticide Toxicity]]