Changes

==Platelet dysfunction==

==Platelet dysfunction==

Bleeding disorders may occur if platelets are deficient ('''thrombocytopaenia''') or if the platelets are unable to function adequately ('''thrombocytopathia''').  [[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]] (ITP) is one common cause of thrombocytopaenia and this may be a primary or secondary disease.  '''Thrombocytosis''' refers to an increase in the blood platelet concentration above the normal level.

Bleeding disorders may occur if platelets are deficient ('''thrombocytopaenia''') or if the platelets are unable to function adequately ('''thrombocytopathia''').  [[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]] (ITP) is one common cause of thrombocytopaenia and this may be a primary or secondary disease.  '''Thrombocytosis''' refers to an increase in the blood platelet concentration above the normal level, and has no clinical importance except as an indicator of another disease process. Thrombocytopaenia and thrombocytopathia both result in reductions in the effectiveness of primary haemostasis, giving rise to a bleeding disorder.  Since heamorrhage is usually sealed by a fibrin clot, disorders of primary haemostasis tend to be less severe than those caused by deficiencies in the [[Coagulation Factor Deficiency|coagulation factors]].

 

Thrombocytopaenia and thrombocytopathia lead to disorders of primary haemostasis but, in general, this is less serious than the disorders of secondary haemostasis caused by deficiencies in the [[Coagulation Factor Deficiency|coagulation factors]].

==Clotting Factor Abnormalities==

==Clotting Factor Abnormalities==