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→Absorption
The rate of absorption is dependant on the route of administration and the bioavailability of a substance.
The rate of absorption is dependant on the route of administration and the bioavailability of a substance.
The route of administration is significant because of the natural barriers that exist which may prevent or lessen a toxic effect by reducing the dose absorbed. Gastric acid and the low pH of the stomach are significant barriers to the absorption of swallowed substances, but conversley, substances that cause local irritation to the intestinal lining, where most absorption will occur, can enhace uptake as a result of this disruption to the gastrointestinal barrier. In addition, some drugs can increase absorption by utilising transport carrier systems present in the GI tract, and lipid soluble compounds will be more readily absorbed across the GI epithelium. Dermal absorption is more readily achieved in people where there is no fur and an increased vascualarity in the dermis, but dermal absorption in animals is increased in areas where there is abrasions, waterlogged skin of exposure to organic solvents.
The route of administration is significant because of the natural barriers that exist which may prevent or lessen a toxic effect by reducing the dose absorbed. Gastric acid and the low pH of the stomach are significant barriers to the absorption of swallowed substances, but conversely, substances that cause local irritation to the intestinal lining, where most absorption will occur, can enhace uptake as a result of this disruption to the gastrointestinal barrier. In addition, some drugs can increase absorption by utilising transport carrier systems present in the GI tract, and lipid soluble compounds will be more readily absorbed across the GI epithelium. Dermal absorption is more readily achieved in people where there is no fur and an increased vascualarity in the dermis, but dermal absorption in animals is increased in areas where there is abrasions, waterlogged skin of exposure to organic solvents.
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