Changes

===Organ function===

===Organ function===

There are several classes of drugs that are nephrotoxic, and any underlying condition which reduces renal blood flow or known renal failure will increase the toxic effect of the substance. Several classes of antibiotics are to be nephrotoxic - aminoglycosides (particularly neomycin and  streptomycin, sulphonamides, Amphotericin B and Oxytetracycline (cattle and dogs seem particularly susceptible). The coccidiostat Monensin which is commonly added to cattle and chicken feeds is nephrotoxic to horses - it damages muscle tissue too. Other organs which can be specifically affected by drugs include ototoxicity associated with Gentamicin, and liver toxicity from aflatoxins produced by ''Aspergillus'' species that grow in certain cereal grains, most notably corn.

There are several classes of drugs that are nephrotoxic, and any underlying condition which reduces renal blood flow or known renal failure will increase the toxic effect of the substance. Several classes of antibiotics are nephrotoxic - [[Aminoglycosides|aminoglycosides]] (particularly neomycin and  streptomycin, [[sulphonamides]], [[Antifungal Drugs#Polyene Antifungals|Amphotericin B]] and [[Tetracyclines|Oxytetracycline]] (cattle and dogs seem particularly susceptible). The coccidiostat Monensin which is commonly added to cattle and chicken feeds is nephrotoxic to horses - it damages muscle tissue too. Other organs which can be specifically affected by drugs include ototoxicity associated with [[Aminoglycosides#Gentamicin|Gentamicin]], and liver toxicity from aflatoxins produced by ''Aspergillus'' species that grow in certain cereal grains, most notably corn.

==Specific Poisons==

==Specific Poisons==