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Complement Associated Diseases (view source)
Revision as of 10:06, 6 September 2007
, 10:06, 6 September 2007→Alternative Pathway Activation
* C3bB is the only substrate for a plasma enzyme known as Factor D.
* C3bB is the only substrate for a plasma enzyme known as Factor D.
** Factor D splits a small peptide (the Ba peptide) from Factor B.
** Factor D splits a small peptide (the Ba peptide) from Factor B.
*** This splitting generates an active enzyme that splits C3 - C3b¯Bb.
*** This splitting generates C3b¯Bb.
**** An active enzyme that splits C3.
**** The bar indicates an active enzyme.
**** The bar indicates an active enzyme.
* C3b¯Bb acts on C3 to generate more C3b.
* C3b¯Bb acts on C3 to generate more C3b.