Difference between revisions of "Testicular Feminisation"
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(Redirected page to Intersex#Testicular feminisation) |
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− | + | == Aetiology == | |
+ | |||
+ | |||
+ | * Genotype XY as should be in the male. | ||
+ | * Testes develop normally and secrete Androgens and MIH | ||
+ | * Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor. | ||
+ | |||
+ | == Consequence == | ||
+ | |||
+ | * Wolffian Ducts regress, allowing formation of '''female external genetalia''': | ||
+ | ** Labia | ||
+ | ** Clitoris | ||
+ | ** Vagina | ||
+ | * Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression. | ||
+ | * Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''. | ||
+ | |||
+ | |||
+ | |||
+ | [[Category:Reproductive Disorders]] | ||
+ | [[Category:Reproductive Pathology - Dog]] |
Revision as of 14:32, 16 December 2010
Aetiology
- Genotype XY as should be in the male.
- Testes develop normally and secrete Androgens and MIH
- Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
Consequence
- Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
- Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
- Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.