Difference between revisions of "Pancreatic Atrophy, Exocrine"

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*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
 
*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
  
 
+
*[[Exocrine Pancreatic Atrophy in GSDs and Rough Coated Collies|Further Study]][[Category:Pancreas - Degenerative Pathology ]]
 
 
 
 
<big>Extra information for Exocrine Pancreatic Atrophy
 
 
 
Exocrine pancreatic atrophy in GSDs and rough coated collies: an end result of lymphocytic pancreatitis. Wiberg ME et al. Vet Path (1999) 36 530-41</big>
 
 
 
*Histological changes in EPI dogs
 
*Histological changes in the subclinical pancreas (ie; just TLI):
 
*Patchy areas of normal and abnormal exocrine parenchyma
 
*Consistently a marked lymphoid infiltrate (lesser numbers of plasma cells seen, occasional eosinophils), starting in the border zone with gradual loss of the pancreatic parenchyma
 
*Mainly CD3+ T cells, with fewer CD3+ lymphocytes.
 
*Some lymphoid follicles (mainly B cells) scattered throughout.
 
*No associated increase in fibrous connective tissue
 
*Some intra-acinar lymphocytes seen
 
*As tissue destruction continued, ductal structures became more obvious
 
*Apoptosis seen in the acini often in normal looking acini.
 
*Ultrastructure
 
**Degenerative changes in acinar cells – dilation of rER, swelling of mitochondria, nuclear pyknosis, aptotitic bodies
 
*Histology of clinical EPI:
 
**Totally atrophied exocrine pancreas
 
**Some dogs had areas of normal acinar structures
 
**Little inflammation in the border zone
 
**Most of the remaining exocrine pancreas was disorganized, prominent ducts, increased amounts of adipose tissue.
 
**Slight increase in fibrous tissue compared to subclinical phase, but replacement with fat was more prominent than fibrosis.
 
**No ductular epithelial hyperplasia evident
 
*Ultrastructure
 
**Often no remaining acinar cells
 
*Suggests and immune-mediated destruction - ?hereditary
 
*Islet cells usually well preserved in the atrophied pancreas.
 
 
 
 
 
 
 
[[Category:Pancreas - Degenerative Pathology ]]
 
 
[[Category:Pancreatic Diseases - Dog]]
 
[[Category:Pancreatic Diseases - Dog]]
 
[[Category:To_Do_-_Clinical]]
 
[[Category:To_Do_-_Clinical]]

Revision as of 15:31, 16 December 2010

AKA Pancreatic Acinar Athropy (PAA)


Pancreatic atrophy (Image sourced from Bristol Biomed Image Archive with permission)
  • Degeneration of acinar cells ccurs as a sequel to
    • Starvation - loss of zymogen granules
    • Maldigestion
    • Obstruction of the pancreatic ducts by
      • Neoplasm
      • Chronic inflammation and associated fibrosis
      • Foreign bodies (parasites, pancreoliths
    • Specific nutritional deficiencies include: essential amino acids, zinc, copper, selenium

Clinical signs

  • By the time clinical signs of exocrine pancreatic insufficiency (EPI) appear, the pancreas is usually almost totally destroyed
  • Chronic diarrhoea with steatorrhoea and undigested muscle fibres. Large quantities of pale faeces are passed (due to dilution of bile pigment and the presence of undigested fats). The faeces have a characteristic rancid or cheesy odour.
  • Loss of condition despite marked increase in appetite

Macroscopic appearance

  • The pancreas is extremely thin and almost lace-like
  • Primarily acinar tissue affected; the ducts and Islets of Langerhans are relatively normal

Microscopic appearance

  • In these cases the parenchyma is replaced by atypical parenchyma and adipose tissue
  • Irregular, shrunken acini composed of cells with little cytoplasm
  • Some cases show a few areas of apparently normal glandular tissue or foci of cellular infiltraton which have been interpreted as suggesting degenerative changes

Aetiology

  • The underlying cause is not known, possibly due to nutritional imbalances
  • Chronic pancreatitis is a rare cause of EPI
  • Possible hereditary EPI in GSDs and rough coated collies

Diagnosis

  • Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI