Frohlich's Adiposogenital Syndrome

Clinical signs due to a hypothalamic dysfunction.

Decresaed synthesis and release of GnRH means that the pituitary is not stimulated to release FSH or LH at normal levels. Clincally seen as:

• Small, atrophic genitals.
• Feminisation in the male due to lower testosterone release.

Hypothalamus damage also allows incresaed appetite and the animal will be:

• Obese.
• Excess deposition of sub-cut fat.

Compression of local structures also leads to:

• Mental retartdation.
• Diabetes insipidus.
• Visual impairment.