Difference between revisions of "Skin Environmental - Pathology"

Revision as of 16:12, 21 February 2011

Transient erythema may develop into sunburn erythema (warmth, swelling, pain)
Diffusion of inflammatory mediators (e.g. cytokines) from damaged keratinocytes and endothelial cells
Photooxidation of existing melanin -> pigment darkening
Melanogenesis
Immune responses of skin are reduced by UV light

Many immune-mediated cutaneous disease are made worse by sunlight
- Lupus erythematosus
- Dermatomyositis
- Pemphigus erythematosus
Vasculitis in extremities, especially white-haired horses
Grossly:
- Erythematous, well circumscribed crusted lesions or hyperkeratotic plaques
Microscopically:
- Vasculitis of superficial dermal vessels
- Thrombi may be seen

@@ Line 57: / Line 57: @@
-===Solar dermatitis===
+===[[Solar Dermatitis]]===
-*Particularly in white animals and where little or no hair is present
-*Grossly:
-**[[Skin Glossary - Pathology|Erythema, scaling and crusting]]
-**-> Wrinkled nand thickened skin
-** Squamous cell carcinoma or haemangiosarcoma/haemangioma may develop
-*Microscopically:
-**Dyskeratotic cells
-**Intercellular oedema
-**Vacuolated keratinocytes
-**Followed by [[Skin Glossary - Pathology|hyperkeratosis, parakeratosis and acanthosis]]
-**Endothelial swelling
-**Haemorrhage
-**Hyperplasia
-**Dermal fibrosis
-**Dogs may develop actinic [[Skin Glossary - Pathology|comedones]]
-[[Category:Integumentary System - Sunlight Damage]]
 ===[[Photosensitisation]]===