Difference between revisions of "Pemphigus"
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| Line 3: | Line 3: | ||
*Types: | *Types: | ||
**'''Pemphigus vulgaris''' | **'''Pemphigus vulgaris''' | ||
| + | ***'''Pathogenesis:''' [[Type II Hypersensitivity|Type II hypersensitivity]] | ||
***Rare, severe form | ***Rare, severe form | ||
***Cats and dogs | ***Cats and dogs | ||
| Line 38: | Line 39: | ||
[[Category:Oral Cavity - Immune Mediated Pathology]] | [[Category:Oral Cavity - Immune Mediated Pathology]] | ||
[[Category:To_Do_-_Clinical]] | [[Category:To_Do_-_Clinical]] | ||
| + | [[Category:Antibody Mediated Autoimmune Diseases]] | ||
| + | [[Category:To Do - Blood]] | ||
Revision as of 17:03, 22 February 2011
- Blistering diseases
- Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
- Types:
- Pemphigus vulgaris
- Pathogenesis: Type II hypersensitivity
- Rare, severe form
- Cats and dogs
- Vesicles or bullae -> erosions and ulcers
- Involves oral cavity, mucocutaneous junctions and skin
- Microscopically:
- Suprabasilar vesiculation and row of basal cells adhering to basement membrane
- Superficial perivascular dermatitis
- Pemphigus vegetans
- Rare
- Dogs
- Involves the trunk
- Mild version of P. vulgaris
- Vesicopustular dermatitis + epidermal hyperplasia -> papillomatous formations
- Pemphigus foliaceus
- More common
- Cats, dogs, horses, goats
- Localised lesions or generalised
- Symmetrical vesicular or pustular dermatitis, crusts, scales, alopecia
- Microscopically:
- Acantholytic cells
- Subcorneal or intragranular pustules
- In third of equine or canine cases eosinophils are predominant
- Pemphigus erythematosus
- Cats and dogs
- Mild form of P. foliaceus
- Usually involves only face and external ears
- Pemphigus vulgaris
Autoimmune
- Occasionally see vesicles on the oral mucosa. associated with autoimmune diseases such as Pemphigus vulgaris.