Difference between revisions of "Bones Metabolic - Pathology"
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+ | ===[[Hypovitaminosis A]]=== | ||
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+ | ===Hypervitaminosis A=== | ||
+ | [[Image:Hypervitaminosis A.jpg|right|thumb|100px|<small><center>Hypervitaminosis A (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] | ||
+ | *Main lesions: | ||
+ | **Injury to growth cartilage -> [[Bones - Anatomy & Physiology|premature closure of growth plate]] | ||
+ | **[[Bones Degenerative - Pathology#Osteoporosis (Atrophy)|Osteoporosis]] | ||
+ | **'''Exostoses''' | ||
+ | **[[Musculoskeletal Terminology - Pathology|Osteophyte]] formation in prolonged exposure | ||
+ | *In cats fed bovine liver for prolonged periods | ||
+ | **Rich in vitamin A in grazing animals | ||
+ | **Vertebrae fuse with each other due to bone proliferation - '''cervical spondylosis''' ('''ankylosing exostosis''' of the vertebral column), especially in the neck | ||
+ | *Can also be teratogenic, especially in pigs ([[Cleft Palate|cleft plate]] and abortions) | ||
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+ | [[Category:Bones - Metabolic Pathology]] | ||
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+ | ===Hypervitaminosis D=== | ||
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+ | *May be of dietary or iatrogenic origin (has narrow safety margin) | ||
+ | *Key features are hypercalcaemia with metastatic calcification of soft tissues | ||
+ | *'''Acute poisoning''' | ||
+ | **In dogs and cats often from rodenticides containing cholecalciferol | ||
+ | **Grossly: | ||
+ | ***Gastrointestinal haemorrhage | ||
+ | ***Foci of [[Myocardial Mineralisation|myocardial discoloration]] | ||
+ | **Microscopically: | ||
+ | ***Mucosal haemorrhage | ||
+ | ***Necrosis of crypts | ||
+ | ***Focal myocardial necrosis | ||
+ | ***Mineralisation of intestinal mucosa, [[Arterial Calcification#Medial calcification|blood vessel walls]], [[Pulmonary Calcification|lungs]] and kidneys | ||
+ | *'''Chronic poisoning''' | ||
+ | **Grossly: | ||
+ | ***Intense [[Bones - Anatomy & Physiology|osteoclastic activity]] -> active resorption of bone, especially [[Bones - Anatomy & Physiology|trabecular]] | ||
+ | **Microscopically: | ||
+ | ***Excessive production of [[Bones - Anatomy & Physiology|osteoid]] - appears both eosinophilic and basophilic in different places | ||
+ | ***Marrow cavity may be obliterated | ||
+ | ***Mineralisation of soft tissues, especially [[Arterial Calcification|blood vessel walls]] | ||
+ | **Due to inhibition of [[Calcium|Parathyroid Hormone (PTH)|PTH]] and increase of [[Calcium#Calcitonin|calcitonin]] | ||
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+ | [[Category:Bones - Metabolic Pathology]] | ||
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+ | ===Fluorine poisoning=== | ||
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+ | *F is widespread in nature | ||
+ | *Pastures may be contaminated by industrial processes (e.g. brick manufacture) | ||
+ | *'''Acute poisoning''': | ||
+ | **Gastroenteritis | ||
+ | **Nephrosis | ||
+ | *'''Chronic poisoning''': | ||
+ | **''Dental abnormalities'' | ||
+ | ***Intoxication during teeth development | ||
+ | ***Foci of poor enamel formation - yellow, dark brown/black, chalky | ||
+ | ***Irregular wear of teeth, chip easily | ||
+ | **''Osteodystrophy = Fluorosis'' | ||
+ | ***Generalised skeletal disturbance | ||
+ | ***Most affected are metatarsals and mandibles | ||
+ | ***Periosteal hyperostosis + endosteal bone resorption -> thickened bones with enlarged marrow cavities | ||
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+ | [[Category:Bones - Metabolic Pathology]] | ||
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+ | ===Lead poisoning=== | ||
+ | |||
+ | *Lead can bind to mineral portion of bone and cartilage | ||
+ | *In young animals ingesting large dose at once | ||
+ | ** -> Lead induced malfunction of osteoclasts | ||
+ | ** -> Transverse band of increased density on radiographs of metaphysis = "lead line" = [[Retention of Elongated Primary Trabeculae|growth retardation lattice]] | ||
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+ | [[Category:Bones - Metabolic Pathology]] | ||
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+ | [[Category:Musculoskeletal System - Pathology]] |
Revision as of 18:53, 27 February 2011
Hypovitaminosis A
Hypervitaminosis A
- Main lesions:
- Injury to growth cartilage -> premature closure of growth plate
- Osteoporosis
- Exostoses
- Osteophyte formation in prolonged exposure
- In cats fed bovine liver for prolonged periods
- Rich in vitamin A in grazing animals
- Vertebrae fuse with each other due to bone proliferation - cervical spondylosis (ankylosing exostosis of the vertebral column), especially in the neck
- Can also be teratogenic, especially in pigs (cleft plate and abortions)
Hypervitaminosis D
- May be of dietary or iatrogenic origin (has narrow safety margin)
- Key features are hypercalcaemia with metastatic calcification of soft tissues
- Acute poisoning
- In dogs and cats often from rodenticides containing cholecalciferol
- Grossly:
- Gastrointestinal haemorrhage
- Foci of myocardial discoloration
- Microscopically:
- Mucosal haemorrhage
- Necrosis of crypts
- Focal myocardial necrosis
- Mineralisation of intestinal mucosa, blood vessel walls, lungs and kidneys
- Chronic poisoning
- Grossly:
- Intense osteoclastic activity -> active resorption of bone, especially trabecular
- Microscopically:
- Excessive production of osteoid - appears both eosinophilic and basophilic in different places
- Marrow cavity may be obliterated
- Mineralisation of soft tissues, especially blood vessel walls
- Due to inhibition of Parathyroid Hormone (PTH)|PTH and increase of calcitonin
- Grossly:
Fluorine poisoning
- F is widespread in nature
- Pastures may be contaminated by industrial processes (e.g. brick manufacture)
- Acute poisoning:
- Gastroenteritis
- Nephrosis
- Chronic poisoning:
- Dental abnormalities
- Intoxication during teeth development
- Foci of poor enamel formation - yellow, dark brown/black, chalky
- Irregular wear of teeth, chip easily
- Osteodystrophy = Fluorosis
- Generalised skeletal disturbance
- Most affected are metatarsals and mandibles
- Periosteal hyperostosis + endosteal bone resorption -> thickened bones with enlarged marrow cavities
- Dental abnormalities
Lead poisoning
- Lead can bind to mineral portion of bone and cartilage
- In young animals ingesting large dose at once
- -> Lead induced malfunction of osteoclasts
- -> Transverse band of increased density on radiographs of metaphysis = "lead line" = growth retardation lattice