Difference between revisions of "Non-Infectious Arthritis"
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(Created page with " *No causative agent has been found *Seem to be immune-mediated diseases ===Erosive=== ====Rheumatoid arthritis==== *Occurs in the dog, mainly smaller breeds *Uncommon *Progre...") |
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| + | |||
*No causative agent has been found | *No causative agent has been found | ||
*Seem to be immune-mediated diseases | *Seem to be immune-mediated diseases | ||
| Line 5: | Line 6: | ||
===Erosive=== | ===Erosive=== | ||
| − | ==== | + | ====Rheumatoid arthritis==== |
| + | *Occurs in the dog, mainly smaller breeds | ||
| + | *Uncommon | ||
| + | *Progressive erosive polyarthritis | ||
| + | *Mostly involves elbows, stifles, carpal and tarsal joints | ||
| + | *Grossly: | ||
| + | **Marked villus hypertrophy of synovial membrane | ||
| + | **Cartilage erosion | ||
| + | **[[Musculoskeletal Terminology - Pathology|Pannus and periarticular osteophyte]] formation | ||
| + | **In severe cases ankylosis | ||
| + | *Histologically: | ||
| + | **Hyperplasia of lining cells | ||
| + | **Proliferative synovitis | ||
| + | **Synovial membrane has fibrin deposits | ||
| + | **Lymphoid and plasma cell infiltration | ||
| + | **Surrounding haemorrhagic areas | ||
| + | **Macrophages containing [[Pigmentation - Pathology#Haemosiderin|haemosiderin]] | ||
| + | **Connective tissue may contain foci of necrosis | ||
| + | **Areas of erosion of peripheral articular cartilage and underlying subchondral bone | ||
| + | *Pathogenesis: | ||
| + | **May involve deposition of immune complexes within joints | ||
| + | **Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation | ||
| Line 16: | Line 38: | ||
**Anaemia | **Anaemia | ||
**Thrombocytopaenia | **Thrombocytopaenia | ||
| − | **[[ | + | **[[Muscles Inflammatory - Pathology#Myositis|Polymyositis]] |
| − | **[[Glomerulonephritis|Glomerulonephritis]] | + | **[[Kidney Glomerular Disease - Pathology#Glomerulonephritis|Glomerulonephritis]] |
| Line 28: | Line 50: | ||
====Gout==== | ====Gout==== | ||
| − | *Occurs in humans, | + | *Occurs in humans, reptiles and birds (have no uricase enzyme) |
*The urate triggers inflammation | *The urate triggers inflammation | ||
[[Category:Arthritis]] | [[Category:Arthritis]] | ||
Revision as of 16:18, 3 March 2011
- No causative agent has been found
- Seem to be immune-mediated diseases
Erosive
Rheumatoid arthritis
- Occurs in the dog, mainly smaller breeds
- Uncommon
- Progressive erosive polyarthritis
- Mostly involves elbows, stifles, carpal and tarsal joints
- Grossly:
- Marked villus hypertrophy of synovial membrane
- Cartilage erosion
- Pannus and periarticular osteophyte formation
- In severe cases ankylosis
- Histologically:
- Hyperplasia of lining cells
- Proliferative synovitis
- Synovial membrane has fibrin deposits
- Lymphoid and plasma cell infiltration
- Surrounding haemorrhagic areas
- Macrophages containing haemosiderin
- Connective tissue may contain foci of necrosis
- Areas of erosion of peripheral articular cartilage and underlying subchondral bone
- Pathogenesis:
- May involve deposition of immune complexes within joints
- Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation
Non-erosive
Systemic lupus erythematosus (SLE)
- Occurs in dogs
- Clinical signs:
- Anaemia
- Thrombocytopaenia
- Polymyositis
- Glomerulonephritis
In chronic diseases
- E.g. pyometra, otitis externa, endocarditis, enteritis
- Can lead to immune complex deposition in joints
Gout
- Occurs in humans, reptiles and birds (have no uricase enzyme)
- The urate triggers inflammation