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===Response to injury===
===Response to injury===
*Limited array of ways in which to respond to injury
*Limited array of ways in which to respond to injury
**[[Muscles Degenerative - Pathology#Degeneration|Degeneration]]
**[[:Category:Muscles - Degenerative Pathology|Degeneration]]
**[[Muscles Degenerative - Pathology#Necrosis|Necrosis]]
**[[Muscle Necrosis|Necrosis]]
**[[Muscle Regeneration - Anatomy & Physiology|Regeneration]]
**Regeneration
**[[Muscles Degenerative - Pathology#Atrophy|Atrophy]]
**[[Muscle Atrophy|Atrophy]]
**[[Muscles Hyperplastic and Neoplastic - Pathology#Hypertrophy|Hypertrophy]]
**[[Muscle Hypertrophy|Hypertrophy]]
*Large number of factors indicing the changes above, e.g.:
*Large number of factors indicing the changes above, e.g.:
**Nutritional deficiencies
**Nutritional deficiencies
**Ichaemia
**Ichaemia
**[[Muscles Developmental - Pathology|Hereditary diseases]]
**[[:Category:Muscles - Developmental Pathology|Hereditary diseases]]
**If these conditions are not met (e.g. severe thermal damage) '''fibrosis''' will occur
**If these conditions are not met (e.g. severe thermal damage) '''fibrosis''' will occur
*Stages:
*Stages:
#Nuclei in [[Muscles Degenerative - Pathology#Necrosis|necrotic segement]] disappear, hyalinased sarcoplasm due to loss of normal myofibrillar structure, may separate from adjacent normal myofibrils and/or [[Muscles Degenerative - Pathology#Calcification|mineralise]]
#Nuclei in [[Muscle Necrosis|necrotic segement]] disappear, hyalinased sarcoplasm due to loss of normal myofibrillar structure, may separate from adjacent normal myofibrils and/or [[Muscle Calcification|mineralise]]
#Monocytes from capillaries -> macrophages in necrotic portion, satellite cells swell -> vesicular with prominent nucleoli -> mitosis (within 1-4 days after initial injury)
#Monocytes from capillaries -> macrophages in necrotic portion, satellite cells swell -> vesicular with prominent nucleoli -> mitosis (within 1-4 days after initial injury)
#Satellite cells move to centre
#Satellite cells move to centre
*Regeneration by '''budding'''
*Regeneration by '''budding'''
**When conditions are not optimal, disrupted sacrolemma
**When conditions are not optimal, disrupted sacrolemma
**E.g. injection of irritating substance, trauma, [[Muscles Degenerative - Pathology#Ischaemia|infarction]]
**E.g. injection of irritating substance, trauma, [[Muscle Ischaemia|infarction]]
**Myoblasts proliferate -> sacrolamma bulges from cut part -> club-shaped with numerous central nuclei = muscle giant cells
**Myoblasts proliferate -> sacrolamma bulges from cut part -> club-shaped with numerous central nuclei = muscle giant cells
*Monophasic lesions - all at same phase above
*Monophasic lesions - all at same phase above
[[Category:Muscles - Pathology]]