Difference between revisions of "CNS Inflammation - Pathology"

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#redirect[[:Category:Central Nervous System - Inflammatory Pathology]]
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[[Central Nervous System Inflammation Overview]]
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[[Central Nervous System Infectious Inflammation]]
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==[[:Category:CNS Non-Infectious Inflammatory Diseases]]==
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===[[Granulomatous Meningoencephalitis]]===
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(GME)
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* An [[CNS Idiopathic Conditions - Pathology|idiopathic CNS conditon]]
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* May occur as:
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** A disseminated disease
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** A focal mass lesion
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** A primary occular disease
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* Brainstem signs are common, although the forebrain is primarily affected.
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* May be incorrectly diagnosed as lymphoma.
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* Changes are apparent in the CSF.
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** There is usually a mononucloear pleocytosis.
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** Sometimes only protein is elveated.
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* Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
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** However, biopsy is required for a definative diagnosis.
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* Life span is between 6 months and 1 year from diagnosis.
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====Treatment====
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* Immunosuppression:
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** Corticosteroids
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** Azathioprine
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** Cycophosphamide
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* Surgery
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** This is only appropriate if there is a focal mass.
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* Radiation therapy.
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[[Necrotising Meningoencephalitis]]
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[[:Category:CNS Non-Infectious Inflammatory Diseases]]
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===Pug Encephalitis===
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* A [[CNS Idiopathic Conditions - Pathology|CNS idiopathic condition]]
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* Affects pugs.
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** Similar conditions are seen in yorkshire and maltese terriers.
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* Officially known as necrotising meningoencephalitis of small dogs.
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* Characterised by histological forebrain inflammation and necrosis.
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* The disease is uniformly fatal.
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** Corticosterid treatment has no effect.
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[:Category:CNS Non-Infectious Inflammatory Diseases]]

Revision as of 12:52, 8 March 2011

Central Nervous System Inflammation Overview


Central Nervous System Infectious Inflammation



Category:CNS Non-Infectious Inflammatory Diseases

Granulomatous Meningoencephalitis

(GME)
  • An idiopathic CNS conditon
  • May occur as:
    • A disseminated disease
    • A focal mass lesion
    • A primary occular disease
  • Brainstem signs are common, although the forebrain is primarily affected.
  • May be incorrectly diagnosed as lymphoma.
  • Changes are apparent in the CSF.
    • There is usually a mononucloear pleocytosis.
    • Sometimes only protein is elveated.
  • Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
    • However, biopsy is required for a definative diagnosis.
  • Life span is between 6 months and 1 year from diagnosis.

Treatment

  • Immunosuppression:
    • Corticosteroids
    • Azathioprine
    • Cycophosphamide
  • Surgery
    • This is only appropriate if there is a focal mass.
  • Radiation therapy.

Necrotising Meningoencephalitis

Category:CNS Non-Infectious Inflammatory Diseases


Pug Encephalitis

  • A CNS idiopathic condition
  • Affects pugs.
    • Similar conditions are seen in yorkshire and maltese terriers.
  • Officially known as necrotising meningoencephalitis of small dogs.
  • Characterised by histological forebrain inflammation and necrosis.
  • The disease is uniformly fatal.
    • Corticosterid treatment has no effect.


[:Category:CNS Non-Infectious Inflammatory Diseases]]

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