Difference between revisions of "Mycoplasma synoviae"

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{{Podcasts
 
|link = https://bloomsbury.mediacore.tv/podcasts/wikivet-english/mycoplasma-synoviae}}
 
 
{{Taxobox
 
{{Taxobox
 
|name = ''Mycoplasma synoviae''
 
|name = ''Mycoplasma synoviae''
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''M. synoviae'' causes '''[[Bacteria |bacterial]]''' disease affecting the '''joints, bones''' and [[Avian Respiration - Anatomy & Physiology|'''respiratory''' system of '''birds''']]. It is one of the [[Mycoplasmas |mycoplasma]] genus of bacteria.
 
''M. synoviae'' causes '''[[Bacteria |bacterial]]''' disease affecting the '''joints, bones''' and [[Avian Respiration - Anatomy & Physiology|'''respiratory''' system of '''birds''']]. It is one of the [[Mycoplasmas |mycoplasma]] genus of bacteria.
  
''M; synoviae'' shares some antigens with [[Mycoplasma gallisepticum |''M. gallisepticum'']] which causes chronic respiratory disease in poultry, but is distinct by most serological tests.
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It is closely related to [[Mycoplasma gallisepticum |''M. gallisepticum'']] which causes chronic respiratory disease in poultry.
  
''M. synoviae'' is endemic in parts of Europe and causes significant production losses particularly in '''egg production'''. Very recently the mycoplasma has been associated with eggshell apex abnormalities (EAA)<ref>Catania, S., Bilato, D., Gobbo, F., Granato, A., Iob, L and Nicholas R.A.J. (2010) '''Treatment of egg-shell abnormalities and reduced egg production caused by ''Mycoplasma synoviae'' infection.''' ''Avian Diseases'' 54, 961-964</ref>.
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''M. synoviae'' is endemic in parts of Europe and causes significant production losses particularly in '''egg production'''.
  
 
==Distribution==
 
==Distribution==
Thought to be worldwide but recording is unreliable.  
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Thought to likely be worldwide but recording is unreliable.  
  
 
Mycoplasma can be '''transmitted''' to progeny through '''eggs''' and through '''direct and indirect contact''' between birds.
 
Mycoplasma can be '''transmitted''' to progeny through '''eggs''' and through '''direct and indirect contact''' between birds.
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Torticollis and other neurological signs may occur in some severe cases.
 
Torticollis and other neurological signs may occur in some severe cases.
 
EAA is characterised by defects at the apex (pointed end) of the egg consisting of sharp clearly defined discoloured zones which are thin, soft and fragile. It can result in a significant drop in egg quality and production.
 
  
 
==Diagnosis==
 
==Diagnosis==
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''M. synoviae'' can then be definitively identified by '''[[immunofluorescence]]''' and '''PCR'''.
 
''M. synoviae'' can then be definitively identified by '''[[immunofluorescence]]''' and '''PCR'''.
  
[[ELISA testing |'''ELISAs''']] can be used for serological diagnosis and are excellent for detecting antibodies in egg yolk which is valuable for flock status investigation. However the slide agglutination test (SAT) is still widely used in industry.
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[[ELISA testing |'''ELISA''']] can be used for serological diagnosis and are excellent for detecting antibodies in egg yolk which is valuable for flock status investigation.
 
 
Specific immunoblotting tests are available in some specialist laboratories to confirm results of the ELISAs and SATs.
 
  
 
==Treatment==
 
==Treatment==
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Control is hampered by the increasing resistance of ''M. synoviae'' to antibiotics.  
 
Control is hampered by the increasing resistance of ''M. synoviae'' to antibiotics.  
  
A vaccine containing a temperature-sensitive strain (MS-H) of Mycoplasma synoviae is currently used in many countries around the world. The duration of protective immunity is at least 40 weeks and has been shown to be protective against EAA.
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No vaccine is available and infection is difficult to control due its aerosolic, vertical and contact transmission.
  
  
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==References==
 
==References==
 
<references/>
 
<references/>
{{CABI source
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Animal Health & ProductIon Compendium, '''''Mycoplasma synoviae'' datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
|datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=74542&loadmodule=datasheet&page=2144&site=160 ''Mycoplasma synoviae''] and [http://www.cabi.org/ahpc/?compid=3&dsid=74552&loadmodule=datasheet&page=2144&site=160 ''Mycoplasma synoviae'' infections]
 
|date =6 June 2011
 
}}
 
<br><br>
 
  
{{Robin Nicholas
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Animal Health & ProductIon Compendium, '''''Mycoplasma synoviae'' infections datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
|date = 31 August 2011
 
}}
 
  
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{{review}}
 
[[Category:Mycoplasmas]]
 
[[Category:Mycoplasmas]]
 
[[Category:Avian Bacteria]]
 
[[Category:Avian Bacteria]]
 
[[Category:Respiratory Diseases - Birds]]
 
[[Category:Respiratory Diseases - Birds]]
[[Category:Musculoskeletal Diseases - Birds]]
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[[Category:CABI Expert Review]]
[[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]]
 

Revision as of 23:03, 20 June 2011

Mycoplasma synoviae
Phylum Firmicutes
Class Mollicutes
Order Mycoplasmatales
Family Mycoplasmataceae
Genus Mycoplasma
Species M.synoviae

Also Known As: Infectious SynovitisAvian MycoplasmosisInfectious SinusitisMycoplasma Arthritis

Introduction

M. synoviae causes bacterial disease affecting the joints, bones and respiratory system of birds. It is one of the mycoplasma genus of bacteria.

It is closely related to M. gallisepticum which causes chronic respiratory disease in poultry.

M. synoviae is endemic in parts of Europe and causes significant production losses particularly in egg production.

Distribution

Thought to likely be worldwide but recording is unreliable.

Mycoplasma can be transmitted to progeny through eggs and through direct and indirect contact between birds.

Signalment

The bacterium affects mainly chickens and turkeys, with chickens being the most susceptible. It can also affect game and wild birds.

Clinical Signs

Most birds exhibit lameness, abnormal curvature of the limbs, deviation of the limbs and feet and a stiff gait. Dehydration and decreased production usually manifest and birds are reluctant to move.

Tachypnoea, sneezing, purulent nasal discharge and open mouth breathing are common but non-specific.

Torticollis and other neurological signs may occur in some severe cases.

Diagnosis

Clinical signs and necropsy findings are suggestive but not pathognomonic so laboratory diagnosis is necessary.

On post-mortem, air sacculitis and arthritis with a caseous exudate are evident.

Bacteria can be isolated and cultured from wet swabs of the trachea, oropharynx, eye, nose or cloaca in live birds. If sampling a dead bird, sterile samples of synovial fluid and air sac samples should be taken.

M. synoviae can then be definitively identified by immunofluorescence and PCR.

ELISA can be used for serological diagnosis and are excellent for detecting antibodies in egg yolk which is valuable for flock status investigation.

Treatment

M. synoviae is susceptible to tilmicosin, tylosin, enrofloxacin and oxytetacyclines in vitro but resistance is increasing in vivo.

Eggs can be dipped in cold chlortetracycline antibiotic solution for 15-20 minutes or heat treated to 46-47⁰ for 11-14 hours prior to incubation.

Control

Control is hampered by the increasing resistance of M. synoviae to antibiotics.

No vaccine is available and infection is difficult to control due its aerosolic, vertical and contact transmission.



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References

Animal Health & ProductIon Compendium, Mycoplasma synoviae datasheet, accessed 06/06/2011 @ http://www.cabi.org/ahpc/

Animal Health & ProductIon Compendium, Mycoplasma synoviae infections datasheet, accessed 06/06/2011 @ http://www.cabi.org/ahpc/