Difference between revisions of "Blue Eye Disease"
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| − | + | Also known as: '''''Blue-eye'''''—'''''BE'''''—'''''Blue eye syndrome'''''—'''''Porcine paramyxovirus blue eye disease'''''—'''''PPBED'''''. | |
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| − | Also known as: '''''Blue-eye''''' — '''''BE''''' — '''''Blue | ||
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==Introduction== | ==Introduction== | ||
| − | Blue eye disease is caused by the virus '''''Blue-eye paramyxovirus ( | + | Blue eye disease is caused by the virus [[Blue-Eye Paramyxovirus|'''''Blue-eye paramyxovirus (BEP)''''']]. It causes '''nervous, reproductive''' and '''respiratory signs''' in its domestic host, the pig. The disease is not considered a zoonosis. |
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| − | It causes '''nervous, reproductive''' and '''respiratory signs''' in its domestic host, the pig. The disease is not considered a zoonosis. | ||
==Signalment== | ==Signalment== | ||
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The disease affects '''all age ranges of pigs''' and also causes '''reproductive disorder in the boar'''. | The disease affects '''all age ranges of pigs''' and also causes '''reproductive disorder in the boar'''. | ||
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'''Piglets and Weaners:''' | '''Piglets and Weaners:''' | ||
| − | Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle | + | Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle fasciculation’s, retarded growth, depression, excitation, head pressing, circling, '''hyperaesthesia''', abnormal behaviour/'''aggression''' and '''coma'''. In piglets the disease also causes '''changes in hair coat''' (dull/rough), '''ocular erosions''', '''enlarged distended bladder''' and '''constipation/reduction in faces or diarrhoea'''. |
'''Sows:''' | '''Sows:''' | ||
| − | In sows the disease causes '''infertility''', reproductive failures, '''embryonic mortality''' | + | In sows the disease causes '''infertility''', reproductive failures, '''embryonic mortality''' and '''return to oestrus in the first third of gestation''' and '''stillbirths, small litters''' and '''mummification in late gestation'''. |
'''Boars:''' | '''Boars:''' | ||
| − | In the boar it causes '''infertility, lack of libido, haemospermia''', and '''orchitis with epidydimitis''' and swelling of the genitals. | + | In the boar it causes male '''infertility, lack of libido, haemospermia''', and '''orchitis with epidydimitis''' and swelling of the genitals. |
==Epidemiology== | ==Epidemiology== | ||
| − | + | The virus can be found in the '''axon of neurons''' from its original site of replication, which is thought to be the '''nasal mucosa and tonsils'''. It is also found in tissues such as lung, liver, spleen, kidney, lymph node, heart and testis; suggesting that the virus is spread hematogenously. | |
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==Distribution== | ==Distribution== | ||
| − | The disease | + | The disease is economically important to '''Central Mexico and its states'''. |
==Diagnosis== | ==Diagnosis== | ||
''Blue-eyed disease'' can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation. | ''Blue-eyed disease'' can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation. | ||
| − | A week after infection a serological response can be seen using a '''virus neutralization test''' and 2 weeks later with a | + | A week after infection a serological response can be seen using a '''virus neutralization test''' and 2 weeks later with a '''haematoglutination inhibition test'''. |
The diagnosis can be '''confirmed''' using '''virus isolation''' on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung. | The diagnosis can be '''confirmed''' using '''virus isolation''' on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung. | ||
| − | During infection ''' | + | During infection '''lymphocytosis''' and '''monocytosis''' may be observed. |
| − | On '''post mortem''' all age ranges have corneal opacity which is mainly unilateral. Piglets show evidence of mild pneumonia, distended bladder and stomach, fibrin strands in the peritoneal cavity and '''congestion in the brain'''. Growers show kidney and '''pericardial haemorrhages''' as well as brain congestion. '''Necrosis of the seminiferous tubules''' and rupture of the epidydimis walls and subsequent abscess and granuloma formation has been documented in boars. | + | On '''post mortem''' all age ranges have corneal opacity which is mainly unilateral. Piglets show evidence of mild pneumonia, distended bladder and stomach, fibrin strands in the peritoneal cavity and '''congestion in the brain'''. Growers show kidney and '''pericardial haemorrhages''' as well as brain congestion. '''Necrosis of the seminiferous tubules''' and rupture of the epidydimis walls and subsequent abscess and granuloma formation has been documented in boars. |
| − | '''Differential | + | '''Differential diagnosis''': [[Porcine Reproductive and Respiratory Syndrome| ''PRRS'']] and [[Suid Herpesvirus 1| ''Pseudorabies'']]. |
==Treatment== | ==Treatment== | ||
There is '''no treatment''' for ''Blue eye disease''. '''Supportive medication''' for respiratory and inflammatory disease should be administered. | There is '''no treatment''' for ''Blue eye disease''. '''Supportive medication''' for respiratory and inflammatory disease should be administered. | ||
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==Control== | ==Control== | ||
| − | The disease is '''self limiting''' and closed herds will have sporadic outbreaks of the disease once a herd is infected. There is '''no approved vaccine''' for the control of blue eye disease but killed-virus vaccine has been shown to be effective <ref name="Stephano et al., 1992"> Stephano, H.A., Olvera, M.J., Garcia, V.P., Ramirez, M.H., Cordoba, D.J. (1992). '''Eficacia de una vacuna inactivada para la prevencion de la infeccion por el paramyxovirus de ojo azul'''. ''Mem 27th Congr Assoc Mex Vet Esp Cerdos. Acapulco, Gro''., 24-28.</ref>. Preventative health programmes to prevent the spread of the disease are the most effective methods of control. Eliminating blue eye disease from affected herds can be achieved by '''closing the herd, running an all-in/all-out systems''', and following good '''washing and disinfecting protocols'''. | + | The disease is '''self limiting''' and closed herds will have sporadic outbreaks of the disease once a herd is infected. There is '''no approved vaccine''' for the control of blue eye disease but killed-virus vaccine has been shown to be effective <ref name="Stephano et al., 1992"> Stephano, H.A., Olvera, M.J., Garcia, V.P., Ramirez, M.H., Cordoba, D.J. (1992). '''Eficacia de una vacuna inactivada para la prevencion de la infeccion por el paramyxovirus de ojo azul'''. ''Mem 27th Congr Assoc Mex Vet Esp Cerdos. Acapulco, Gro''., 24-28.</ref>. Preventative health programmes to prevent the spread of the disease are the most effective methods of control. Eliminating blue eye disease from affected herds can be achieved by '''closing the herd, running an all-in/all-out systems''', and following good '''washing and disinfecting protocols'''. |
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==References== | ==References== | ||
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<references/> | <references/> | ||
| − | {{ | + | {{Learning |
| − | | | + | |flashcards = [[Blue Eye Disease Flashcard]] |
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}} | }} | ||
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| − | [[Category: | + | [[Category:To Do - Jaimie Meagor]] |
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Revision as of 20:23, 28 June 2011
Also known as: Blue-eye—BE—Blue eye syndrome—Porcine paramyxovirus blue eye disease—PPBED.
Introduction
Blue eye disease is caused by the virus Blue-eye paramyxovirus (BEP). It causes nervous, reproductive and respiratory signs in its domestic host, the pig. The disease is not considered a zoonosis.
Signalment
The disease affects all age ranges of pigs and also causes reproductive disorder in the boar.
Clinical Signs
Generally pigs suffer from anorexia, weight loss, reluctance to move, dehydration, periorbital and conjunctival swelling (chemosis) and purulent/serous ocular discharge and corneal opacity. The virus also causes neurological signs including tetraparesis, opisthotonus, dysmetria, proprioceptive disorders, tremors, nystagmus mydriasis, blindness, decreased or absent menace response and respiratory signs; tachypnea, dyspnea, and open mouthed breathing.
In addition the virus affects different age group and sexes in the following ways:
Piglets and Weaners:
Piglet and weaners suffer from prostration, hind limb stiffness, generalised weakness, muscle fasciculation’s, retarded growth, depression, excitation, head pressing, circling, hyperaesthesia, abnormal behaviour/aggression and coma. In piglets the disease also causes changes in hair coat (dull/rough), ocular erosions, enlarged distended bladder and constipation/reduction in faces or diarrhoea.
Sows:
In sows the disease causes infertility, reproductive failures, embryonic mortality and return to oestrus in the first third of gestation and stillbirths, small litters and mummification in late gestation.
Boars:
In the boar it causes male infertility, lack of libido, haemospermia, and orchitis with epidydimitis and swelling of the genitals.
Epidemiology
The virus can be found in the axon of neurons from its original site of replication, which is thought to be the nasal mucosa and tonsils. It is also found in tissues such as lung, liver, spleen, kidney, lymph node, heart and testis; suggesting that the virus is spread hematogenously.
Distribution
The disease is economically important to Central Mexico and its states.
Diagnosis
Blue-eyed disease can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation.
A week after infection a serological response can be seen using a virus neutralization test and 2 weeks later with a haematoglutination inhibition test.
The diagnosis can be confirmed using virus isolation on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung.
During infection lymphocytosis and monocytosis may be observed.
On post mortem all age ranges have corneal opacity which is mainly unilateral. Piglets show evidence of mild pneumonia, distended bladder and stomach, fibrin strands in the peritoneal cavity and congestion in the brain. Growers show kidney and pericardial haemorrhages as well as brain congestion. Necrosis of the seminiferous tubules and rupture of the epidydimis walls and subsequent abscess and granuloma formation has been documented in boars.
Differential diagnosis: PRRS and Pseudorabies.
Treatment
There is no treatment for Blue eye disease. Supportive medication for respiratory and inflammatory disease should be administered.
Control
The disease is self limiting and closed herds will have sporadic outbreaks of the disease once a herd is infected. There is no approved vaccine for the control of blue eye disease but killed-virus vaccine has been shown to be effective [1]. Preventative health programmes to prevent the spread of the disease are the most effective methods of control. Eliminating blue eye disease from affected herds can be achieved by closing the herd, running an all-in/all-out systems, and following good washing and disinfecting protocols.
References
- ↑ Stephano, H.A., Olvera, M.J., Garcia, V.P., Ramirez, M.H., Cordoba, D.J. (1992). Eficacia de una vacuna inactivada para la prevencion de la infeccion por el paramyxovirus de ojo azul. Mem 27th Congr Assoc Mex Vet Esp Cerdos. Acapulco, Gro., 24-28.
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Blue Eye Disease Flashcard |