Difference between revisions of "Bacterial Meningoencephalitis - Cattle"

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Also Known As – '''''Meningitis – Encephalitis - Septicaemia - Bacteraemia - Navel Ill '''''
  
Also Known As: '''''Meningitis — Encephalitis — Septicaemia — Bacteraemia — Navel Ill '''''
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Caused By ''[[Escherichia coli]] [[Haemophilus somnus]] [[Listeria monocytogenes]] [[Arcanobacterium pyogenes]] - [[Mannheimia haemolytica]] [[Streptococci|Streptococcus spp.]] [[Pasteurella species|Pasteurella spp.]] - and many other opportunistic bacterial species.''
 
 
Caused By: ''[[Escherichia coli]] [[Haemophilus somnus]] [[Listeria monocytogenes]] [[Arcanobacterium pyogenes]] [[Mannheimia haemolytica]] [[Streptococci|Streptococcus spp.]] [[Pasteurella species|Pasteurella spp.]] and many other opportunistic bacterial species.''
 
  
 
==Introduction==
 
==Introduction==
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==Clinical Signs==
 
==Clinical Signs==
The '''signs of meningitis are often earlier and more pronounced ''' than those of encephalitis and usually include '''pyrexia, hyperaesthesia, neck rigidity and painful paraspinal muscular spasms.'''
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The '''signs of meningitis are often earlier and more pronounced''' than those of encephalitis and usually include '''pyrexia, hyperaesthesia, neck rigidity and painful paraspinal muscular spasms.'''
  
 
'''Encephalitis''' often adds '''depression, blindness, opisthotonus,  paresis/paralysis''' which may be progressive, '''ataxia, cranial nerve deficits, seizures and changes in mentation. '''
 
'''Encephalitis''' often adds '''depression, blindness, opisthotonus,  paresis/paralysis''' which may be progressive, '''ataxia, cranial nerve deficits, seizures and changes in mentation. '''
  
 
==Diagnosis==
 
==Diagnosis==
'''[[Cerebral Spinal Fluid - Anatomy & Physiology|CSF]] analysis''' is the preferred method of diagnosis, usually revealing a '''raised total protein and a sometimes positive culture result'''. The latter is definitive although sometimes difficult to obtain. In farm species however, '''clinical signs''' are often used for a presumptive diagnosis and treatment instigated appropriately.  
+
'''CSF analysis''' is the preferred method of diagnosis, usually revealing a '''raised total protein and a sometimes positive culture result'''. The latter is definitive although sometimes difficult to obtain. In farm species however, '''clinical signs''' are often used for a presumptive diagnosis and treatment instigated appropriately.  
  
 
A '''blood culture will confirm bacteraemia''' which in the presence of neurological signs can confirm a suspicion of bacterial meningitis. This will also allow the causative agent and its sensitivity profile to be identified.
 
A '''blood culture will confirm bacteraemia''' which in the presence of neurological signs can confirm a suspicion of bacterial meningitis. This will also allow the causative agent and its sensitivity profile to be identified.
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On necropsy, the '''meninges and parenchyma are infiltrated by leucocytes and the subarachnoid space is inflamed''', often along its entire length. '''Perivascular cuffing''' often features extensively. Blood vessels within and associated with the CNS may show evidence of '''vasculitis'''. End-stage disease features areas of '''necrosis and malacia''' with a mixed inflammatory infiltrate.
 
On necropsy, the '''meninges and parenchyma are infiltrated by leucocytes and the subarachnoid space is inflamed''', often along its entire length. '''Perivascular cuffing''' often features extensively. Blood vessels within and associated with the CNS may show evidence of '''vasculitis'''. End-stage disease features areas of '''necrosis and malacia''' with a mixed inflammatory infiltrate.
  
[[Listeriosis]] also causes its own pathognomic pathology.
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[[Listeriosis]] also causes its own pathognomic pathology, which is discussed further [[Listeriosis|here]].
  
 
==Treatment==
 
==Treatment==
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Affected neonates also require '''attentive nursing''' in the form of '''nutritional support, fluid therapy, protection from self-trauma and maintenance of temperature and acid: base balance.'''
 
Affected neonates also require '''attentive nursing''' in the form of '''nutritional support, fluid therapy, protection from self-trauma and maintenance of temperature and acid: base balance.'''
  
Treatment is sometimes combined with '''corticosteroids''' to reduce cerebral inflammation, but this should be implemented with care due to immunosuppressive effects,  
+
Treatment is sometimes combined with '''corticosteroids''' to reudce cerebral inflammation, but this should be implemented with care due to immunosuppressive effects,  
  
'''Anticonvulsants''' can also be used when [[seizures]] are prolonged or repetitive.
+
'''Anticonvulsants''' can also be used when seizures are prolonged or repetitive.  
  
 
==Control==
 
==Control==
'''Minimising perinatal stress, ensuring colostrum quality and intake and maintaining hygienic conditions''' for neonates at parturition and also during husbandry and surgical procedures are all vital measures to prevent septicaemia and concurrent bacterial meningoencephalitis.  
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'''Minimising perinatal stress, ensuring colostrum quality and intake and maintaining hygienic conditions''' for neonates and parturition and also during husbandry and surgical procedures are all vital measures to prevent septicaemia and concurrent bacterial meningoencephalitis.  
  
 
{{Learning
 
{{Learning
 
|flashcards = [[Bacterial Meningoencephalitis in Cattle Flashcards]]
 
|flashcards = [[Bacterial Meningoencephalitis in Cattle Flashcards]]
 
[[Cattle Medicine Q&A 07]]
 
 
}}
 
}}
  
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Merck Veterinary Manual, '''Meningitis and Encephalitis''', accessed online 24/07/2011 at http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/101600.htm
 
Merck Veterinary Manual, '''Meningitis and Encephalitis''', accessed online 24/07/2011 at http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/101600.htm
  
 
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[[Category:To Do - Manson review]] [[Category:Neurological Diseases - Cattle]] [[Category:Neurological Diseases - Sheep]]
{{review}}
 
 
 
==Webinars==
 
<rss max="10" highlight="none">https://www.thewebinarvet.com/neurology/webinars/feed</rss>
 
 
 
[[Category:Expert Review - Farm Animal]] [[Category:Neurological Diseases - Cattle]] [[Category:Neurological Diseases - Sheep]]
 

Revision as of 12:46, 24 July 2011

Also Known As – Meningitis – Encephalitis - Septicaemia - Bacteraemia - Navel Ill

Caused By – Escherichia coliHaemophilus somnusListeria monocytogenesArcanobacterium pyogenes - Mannheimia haemolyticaStreptococcus spp.Pasteurella spp. - and many other opportunistic bacterial species.

Introduction

Meningoencephalitis encompasses inflammation of both the meninges (meningitis) and brain (encephalitis). The two often occur simultaneously, as once the blood: brain barrier is penetrated, both structures are accessible and vulnerable.

Infection originates most commonly from haematogenous spread after bacteraemia has occurred, but can also be produced from severe head injuries and thermonecrosis after disbudding/dehorning procedures.

The clinical signs of meningitis often precede those of encephalitis and may dominate for the duration of the illness.

Distribution

Worldwide

Signalment

Disease is most commonly seen in neonatal calves as a result of haematogenous spread of navel infection but can also occur in adult animals, especially Haemophilus somnus. Failure of maternal antibody transfer through inadequate colostrum intake in the first six hours of life is a large contributor to susceptibility to septicaemia and concurrent meningoencephalitis.

Neonates of other species, particularly lambs and foals, can also be affected similarly.

Clinical Signs

The signs of meningitis are often earlier and more pronounced than those of encephalitis and usually include pyrexia, hyperaesthesia, neck rigidity and painful paraspinal muscular spasms.

Encephalitis often adds depression, blindness, opisthotonus, paresis/paralysis which may be progressive, ataxia, cranial nerve deficits, seizures and changes in mentation.

Diagnosis

CSF analysis is the preferred method of diagnosis, usually revealing a raised total protein and a sometimes positive culture result. The latter is definitive although sometimes difficult to obtain. In farm species however, clinical signs are often used for a presumptive diagnosis and treatment instigated appropriately.

A blood culture will confirm bacteraemia which in the presence of neurological signs can confirm a suspicion of bacterial meningitis. This will also allow the causative agent and its sensitivity profile to be identified.

On necropsy, the meninges and parenchyma are infiltrated by leucocytes and the subarachnoid space is inflamed, often along its entire length. Perivascular cuffing often features extensively. Blood vessels within and associated with the CNS may show evidence of vasculitis. End-stage disease features areas of necrosis and malacia with a mixed inflammatory infiltrate.

Listeriosis also causes its own pathognomic pathology, which is discussed further here.

Treatment

Early and aggressive therapy is imperative for a successful outcome.

Prolonged antibiotic therapy is often required and an agent should be chosen that is ideally bacteriocidal and also has good blood: brain barrier penetration. Ampicillin, metronidazole, tetracyclines, trimethoprim-sulphonamides, fluoroquinolones and third generation cephalosporins have all been used with success. Licensing for food production animals should also always be considered.

Affected neonates also require attentive nursing in the form of nutritional support, fluid therapy, protection from self-trauma and maintenance of temperature and acid: base balance.

Treatment is sometimes combined with corticosteroids to reudce cerebral inflammation, but this should be implemented with care due to immunosuppressive effects,

Anticonvulsants can also be used when seizures are prolonged or repetitive.

Control

Minimising perinatal stress, ensuring colostrum quality and intake and maintaining hygienic conditions for neonates and parturition and also during husbandry and surgical procedures are all vital measures to prevent septicaemia and concurrent bacterial meningoencephalitis.


Bacterial Meningoencephalitis - Cattle Learning Resources
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Flashcards
Test your knowledge using flashcard type questions
Bacterial Meningoencephalitis in Cattle Flashcards


References

Haskell, S (2008) Blackwell’s Five-Minute Veterinary Consult: Ruminant. Wiley-Blackwell, Oxford, p104-105.

Merck Veterinary Manual, Meningitis and Encephalitis, accessed online 24/07/2011 at http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/101600.htm