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Endocrine effects on the skin - Pathology (view source)
Revision as of 15:02, 26 October 2011
, 15:02, 26 October 2011→Superficial Necrolytic Dermatopathy
===Pathogenesis===
===Pathogenesis===
<p>General skin changes ('''endocrine alopecia''') seen with endocrine disease include:
<p>General skin changes ('''endocrine alopecia''') seen with endocrine disease include:
*Hypotrichosis.
*[[Hypotrichosis]].
*Alopecia; usually bilaterally symmetric and non-pruritic.
*[[Alopecia]]; usually bilaterally symmetric and non-pruritic.
*Remaining coat is dry and dull
*Remaining coat is dry and dull
*Pigment disturbance.
*Pigment disturbance.
*Retained puppy hair coat, endocrine alopecia, decreased dermal elastin and catagen follicles ('''Flame follicles''').
*Retained puppy hair coat, endocrine alopecia, decreased dermal elastin and catagen follicles ('''Flame follicles''').
===='''Excess GH (hypersomatotropism)'''====
===='''Excess GH ([[hypersomatotropism]])'''====
*Grossly: thick, folded skin on head, neck and extremities, possibly with hypertrichosis
*Grossly: thick, folded skin on head, neck and extremities, possibly with hypertrichosis
*Microscopically: epidermal hyperplasia, dermal fibrosis, mucinous degeneration of dermis
*Microscopically: epidermal hyperplasia, dermal fibrosis, mucinous degeneration of dermis
====[[Hyperoestrogenism|'''Hyperoestrogenism''']]====
====[[Hyperoestrogenism - Dog|'''Hyperoestrogenism''']]====
*Grossly: endocrine alopecia, enlarged vulva and abnormal oestrus cycle in females, gynecomastia, pendulous prepuce or enlarged prostate in males
*Grossly: endocrine alopecia, enlarged vulva and abnormal oestrus cycle in females, gynecomastia, pendulous prepuce or enlarged prostate in males
*Microscopically: telogen follicles, hyperkeratosis and acanthosis or epidermis and follicular infundibulum
*Microscopically: telogen follicles, hyperkeratosis and acanthosis or epidermis and follicular infundibulum
*Castration may temporarily remove symptoms
*Castration may temporarily remove symptoms
===='''Superficial Necrolytic Dermatopathy'''====
===='''[[Superficial Necrolytic Dermatopathy]]'''====
*Also known as ''diabetic dermatopathy, hepatocutaneous syndrome''
*Also known as ''diabetic dermatopathy, hepatocutaneous syndrome''