Difference between revisions of "Immunoglobulins Flashcards"

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{{toplink
 
|linkpage =Immunoglobulins - WikiBlood
 
|linktext =IMMUNOGLOBULINS
 
|sublink1 =Flash Cards - WikiBlood
 
|subtext1 =WIKIBLOOD FLASHCARDS
 
|pagetype =Blood
 
}}
 
 
===Immunoglobulins Structure and Function===
 
===Immunoglobulins Structure and Function===
 
<FlashCard questions="8">
 
<FlashCard questions="8">
 
|q1=What are immunoglobulins also known as?
 
|q1=What are immunoglobulins also known as?
 
|a1=Antibodies
 
|a1=Antibodies
|l1=Immunoglobulins - WikiBlood#Introduction
+
|l1=Immunoglobulins#Introduction
 
|q2=How many domains does the heavy chain have?
 
|q2=How many domains does the heavy chain have?
 
|a2=
 
|a2=
 
*1 variable domain
 
*1 variable domain
 
*3 or 4 constant domains
 
*3 or 4 constant domains
|l2=Immunoglobulins - WikiBlood#Structure
+
|l2=Immunoglobulins#Structure
 
|q3=How many domains does the light chain have?
 
|q3=How many domains does the light chain have?
 
|a3=
 
|a3=
 
*1 variable domain
 
*1 variable domain
 
*1 constant domain
 
*1 constant domain
|l3=Immunoglobulins - WikiBlood#Structure
+
|l3=Immunoglobulins#Structure
 
|q4=What are hypervariable domains?
 
|q4=What are hypervariable domains?
 
|a4=
 
|a4=
 
*Folded pockets of the variable domain into which antibody can bind
 
*Folded pockets of the variable domain into which antibody can bind
 
*Different antibodies have different amino acid sequences within the three variable domains
 
*Different antibodies have different amino acid sequences within the three variable domains
|l4=Immunoglobulins - WikiBlood#Structure
+
|l4=Immunoglobulins#Structure
 
|q5=What does Fab stand for and from which chain is it generated?
 
|q5=What does Fab stand for and from which chain is it generated?
 
|a5=
 
|a5=
 
*Fragment associated with antigen binding
 
*Fragment associated with antigen binding
 
*Light chain
 
*Light chain
|l5=Immunoglobulins - WikiBlood#Structure
+
|l5=Immunoglobulins#Structure
 
|q6=What does Fc stand for and from which chain is it generated?
 
|q6=What does Fc stand for and from which chain is it generated?
 
|a6=
 
|a6=
 
*Constant fragment
 
*Constant fragment
 
*Heavy chain
 
*Heavy chain
|l6=Immunoglobulins - WikiBlood#Structure
+
|l6=Immunoglobulins#Structure
 
|q7=What does the Fc fragment do?
 
|q7=What does the Fc fragment do?
 
|a7=Mediates phagocytosis
 
|a7=Mediates phagocytosis
 
*Triggers inflammation
 
*Triggers inflammation
 
*Targets Ig to certain tissues
 
*Targets Ig to certain tissues
|l7=Immunoglobulins - WikiBlood#Structure
+
|l7=Immunoglobulins#Structure
 
|q8=What are the four major effects of antibodies?
 
|q8=What are the four major effects of antibodies?
 
|a8=
 
|a8=
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*Degranulation of mast cells/eosinophils
 
*Degranulation of mast cells/eosinophils
 
*Complement Fixation
 
*Complement Fixation
|l8=Immunoglobulins - WikiBlood#Function
+
|l8=Immunoglobulins#Function
 
</FlashCard>
 
</FlashCard>
 
===Classes of Immunoglobulin===
 
===Classes of Immunoglobulin===
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|q1=How do the five classes of immunoglobulins vary from each other?
 
|q1=How do the five classes of immunoglobulins vary from each other?
 
|a1=They each have a different composition to their heavy chains
 
|a1=They each have a different composition to their heavy chains
|l1=Immunoglobulins - WikiBlood#Classes
+
|l1=Immunoglobulins#Classes
 
|q2=IgA is specially adapted for function at which type of surface?
 
|q2=IgA is specially adapted for function at which type of surface?
 
|a2=Mucosal surfaces
 
|a2=Mucosal surfaces
|l2=Immunoglobulin A - WikiBlood
+
|l2=Immunoglobulin A
 
|q3=True or False: IgA is a monomer
 
|q3=True or False: IgA is a monomer
 
|a3=
 
|a3=
 
*False
 
*False
 
*IgA is a dimer
 
*IgA is a dimer
|l3=Immunoglobulin A - WikiBlood#Structure
+
|l3=Immunoglobulin A#Structure
 
|q4=What are the functions of IgA?
 
|q4=What are the functions of IgA?
 
|a4=
 
|a4=
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*Resists proteolytic digestion so can function in the gut
 
*Resists proteolytic digestion so can function in the gut
 
*Does not activate the complement system so helps to preserve mucosal integrity
 
*Does not activate the complement system so helps to preserve mucosal integrity
|l4=Immunoglobulin A - WikiBlood#Function
+
|l4=Immunoglobulin A#Function
 
|q5=In which species has IgD been identified?
 
|q5=In which species has IgD been identified?
 
|a5=
 
|a5=
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*Dogs
 
*Dogs
 
*Rodents
 
*Rodents
|l5=Immunoglobulin D - WikiBlood#Function
+
|l5=Immunoglobulin D#Function
 
|q6=What is the main function of IgD?
 
|q6=What is the main function of IgD?
 
|a6=Helps B cell development
 
|a6=Helps B cell development
|l6=Immunoglobulin D - WikiBlood#Function
+
|l6=Immunoglobulin D#Function
 
|q7=True or False: IgE is not a soluble antibody?
 
|q7=True or False: IgE is not a soluble antibody?
 
|a7=True
 
|a7=True
|l7=Immunoglobulin E - WikiBlood
+
|l7=Immunoglobulin E
 
|q8=What are the functions of IgE?
 
|q8=What are the functions of IgE?
 
|a8=
 
|a8=
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*Involved in type I hypersensitivity reactions
 
*Involved in type I hypersensitivity reactions
 
*Involved in producing immunity to parasitic worms and nematode parasites
 
*Involved in producing immunity to parasitic worms and nematode parasites
|l8=Immunoglobulin E - WikiBlood#Function
+
|l8=Immunoglobulin E#Function
 
|q9=True or False: IgG is the smallest antibody and can easily leave the plasma and enter tissue?
 
|q9=True or False: IgG is the smallest antibody and can easily leave the plasma and enter tissue?
 
|a9=True
 
|a9=True
|l9=Immunoglobulin G - WikiBlood
+
|l9=Immunoglobulin G
 
|q10=Where is IgG produced?
 
|q10=Where is IgG produced?
 
|a10=Bone marrow
 
|a10=Bone marrow
 
*Spleen
 
*Spleen
 
*Lymph nodes
 
*Lymph nodes
|l10=Immunoglobulin G - WikiBlood#Production
+
|l10=Immunoglobulin G#Production
 
|q11=What is the function of IgG?
 
|q11=What is the function of IgG?
 
|a11=Activates the classical pathway of the complement cascade
 
|a11=Activates the classical pathway of the complement cascade
*Can act as targets for macrophages, eosinophils and [[Neutrophils - WikiBlood|neutrophils]]
+
*Can act as targets for macrophages, eosinophils and [[Neutrophils|neutrophils]]
 
*Causes agglutination and opsonisation of bacteria
 
*Causes agglutination and opsonisation of bacteria
|l11=Immunoglobulin G - WikiBlood#Function
+
|l11=Immunoglobulin G#Function
 
|q12=True or False: IgM is a monomer
 
|q12=True or False: IgM is a monomer
 
|a12=
 
|a12=
 
*True
 
*True
 
*But it is secreted as a pentamer
 
*But it is secreted as a pentamer
|l12=Immunoglobulin M - WikiBlood#Structure
+
|l12=Immunoglobulin M#Structure
 
|q13=IgM is five times larger than most other antibodies. What effect does this have on its function?
 
|q13=IgM is five times larger than most other antibodies. What effect does this have on its function?
 
|a13=
 
|a13=
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*Does not diffuse quickly or enter tissues readily
 
*Does not diffuse quickly or enter tissues readily
 
*Its concentration in extracellular fluid and lymph is low
 
*Its concentration in extracellular fluid and lymph is low
|l13=Immunoglobulin M - WikiBlood#Production
+
|l13=Immunoglobulin M#Production
 
|q14=What are the main functions of IgM?
 
|q14=What are the main functions of IgM?
 
|a14=
 
|a14=
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*Opsonisation
 
*Opsonisation
 
*Virus neutralisation
 
*Virus neutralisation
|l14=Immunoglobulin M - WikiBlood#Function
+
|l14=Immunoglobulin M#Function
 
</FlashCard>
 
</FlashCard>
 
===Immunoglobulins Variation===
 
===Immunoglobulins Variation===
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*IGH genes
 
*IGH genes
 
*Heavy chain
 
*Heavy chain
|l1=Immunoglobulins - WikiBlood#Variation
+
|l1=Immunoglobulins#Variation
 
|q2=Complete the sentences about IgG subtypes:
 
|q2=Complete the sentences about IgG subtypes:
 
<p>Humans and rodents have ??? IgG subtypes. Dogs have ??? IgG subtypes. Ruminats have ??? IgG subtypes.</p>
 
<p>Humans and rodents have ??? IgG subtypes. Dogs have ??? IgG subtypes. Ruminats have ??? IgG subtypes.</p>
Line 132: Line 125:
 
*three  
 
*three  
 
*three or four
 
*three or four
|l2=Immunoglobulins - WikiBlood#Variation
+
|l2=Immunoglobulins#Variation
 
|q3=What are allotypes?
 
|q3=What are allotypes?
 
|a3=
 
|a3=
 
*Differences in immunoglobulins between individuals of a particular species
 
*Differences in immunoglobulins between individuals of a particular species
 
*Allotypes are inheritable
 
*Allotypes are inheritable
|l3=Immunoglobulins - WikiBlood#Allo & Idiotypes
+
|l3=Immunoglobulins#Allo & Idiotypes
 
|q4=What are idiotypes?
 
|q4=What are idiotypes?
 
|a4=Variations in the sequences of amino acids in the variable regions of the light and heavy chains
 
|a4=Variations in the sequences of amino acids in the variable regions of the light and heavy chains
|l4=Immunoglobulins - WikiBlood#Allo & Idiotypes
+
|l4=Immunoglobulins#Allo & Idiotypes
 
|q5=What is immunoglobulin heavy chain switching?
 
|q5=What is immunoglobulin heavy chain switching?
 
|a5=
 
|a5=
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*Other classes of immunoglobluins are synthesised
 
*Other classes of immunoglobluins are synthesised
 
*The same varibale domains are kept
 
*The same varibale domains are kept
|l5=Immunoglobulins - WikiBlood#Immunoglobulin Class Switching
+
|l5=Immunoglobulins#Immunoglobulin Class Switching
 
|q6=How do different classes of antibody differ from each other?
 
|q6=How do different classes of antibody differ from each other?
 
|a6=
 
|a6=
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*Associated carbohydrate
 
*Associated carbohydrate
 
*Function
 
*Function
|l6=Immunoglobulins - WikiBlood#Immunoglobulin Class Switching
+
|l6=Immunoglobulins#Immunoglobulin Class Switching
 
</FlashCard>
 
</FlashCard>
 +
 +
<br><br>
 +
{{Jim Bee 2007}}
 +
[[Category:Immunology Flashcards]]
 +
[[Category:Immunoglobulins]]

Latest revision as of 16:00, 16 March 2012

Immunoglobulins Structure and Function

Question Answer Article
What are immunoglobulins also known as? Link to Article
How many domains does the heavy chain have? Link to Article
How many domains does the light chain have? Link to Article
What are hypervariable domains? Link to Article
What does Fab stand for and from which chain is it generated? Link to Article
What does Fc stand for and from which chain is it generated? Link to Article
What does the Fc fragment do? Link to Article
What are the four major effects of antibodies? Link to Article


Classes of Immunoglobulin

Question Answer Article
How do the five classes of immunoglobulins vary from each other? Link to Article
IgA is specially adapted for function at which type of surface? Link to Article
True or False: IgA is a monomer Link to Article
What are the functions of IgA? Link to Article
In which species has IgD been identified? Link to Article
What is the main function of IgD? Link to Article
True or False: IgE is not a soluble antibody? Link to Article
What are the functions of IgE? Link to Article
True or False: IgG is the smallest antibody and can easily leave the plasma and enter tissue? Link to Article
Where is IgG produced? Link to Article
What is the function of IgG? Link to Article
True or False: IgM is a monomer Link to Article
IgM is five times larger than most other antibodies. What effect does this have on its function? Link to Article
What are the main functions of IgM? Link to Article


Immunoglobulins Variation

Question Answer Article
Which genes code for the immunoglobulin subtypes and on which chain are they located? Link to Article
Complete the sentences about IgG subtypes:

Humans and rodents have ??? IgG subtypes. Dogs have ??? IgG subtypes. Ruminats have ??? IgG subtypes.

Link to Article
What are allotypes? Link to Article
What are idiotypes? Link to Article
What is immunoglobulin heavy chain switching? Link to Article
How do different classes of antibody differ from each other? Link to Article




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