Difference between revisions of "Humoral Factors of Innate Immune System"

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===Lysozyme===
 
===Lysozyme===
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Lysozyme is one of the major bactericidal agents in secretions and particularly helps to protect vulnerable sites such as the eyes and nasal passages. The lysoszyme exerts bactericidal effects by digesting bacterial cell walls.
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* Lysozyme is one of the major bactericidal agents in secretions
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<br /><br />
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* Helps to protect vulnerable sites such as the eyes and nasal passages
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* Exerts bactericidal effects by digesting bacterial cell walls
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The gram-positive bacteria are more sensitive to lysozyme action than gram-negative bacteria as the outer membrane of gram-negative bacteria helps to protect them.
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** Gram-positive bacteria are more sensitive to lysozyme action than gram-negative bacteria
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** The outer membrane of gram-negative bacteria helps to protect them
  
 
===[[Complement|Complement]]===
 
===[[Complement|Complement]]===
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The complement system is a group of about 30 proteins within the body fluids of all vertebrates and some invertebrates. The main functions of complement are to promote '''[[Phagocytosis|phagocytosis]]''' or causes lysis of an invading organism.
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* The Complement system is a group of about 30 proteins within the body fluids of all vertebrates and some invertebrates
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<br />
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* Complement promotes '''phagocytosis''' or causes lysis of an invading organism
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<br />
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* Complement acts as a cascade, like the blood clotting system
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The complement acts as a cascade, like the blood clotting system. It begins with the the early enzymes in the cascade binding to invading bacteria and fungi as they have an affinity for components of microbial cell membranes. This binding initiates a cascade so that the binding of one molecule will eventually lead to the fixation of millions of later molecules. Some of the the early components act as targets for phagocytes while the later components punch holes in bacteria, causing their lysis.
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** The early enzymes in the cascade are bound to invading bacteria and fungi
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*** They have an affinity for components of microbial cell membranes
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** This binding initiates a cascade so that the binding of one molecule will eventually lead to the fixation of millions of later molecules  
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* The early components act as targets for phagocytes
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* The later components punch holes in bacteria, causing their lysis
  
 
===Interferons===
 
===Interferons===
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The lysozyme and complement have only marginal effects on virus infections because these are intracellular so the body has evolved non-specific mechanisms to protect against viruses with the most notable of these being the interferons.<br />
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* Lysozyme and complement have only marginal effects on virus infections because these are intracellular
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<br />
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** The body has evolved non-specific mechanisms to protect against viruses
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*** The most notable of these is the interferons
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Interferons are small polypeptides produced mainly by virus-infected cells. The main functions are of interferon is to interact with uninfected cells and render them resistant to infection by increasing the production of enzymes that digest viral nucleic acids. The interferon can then also cause an increase in MHC ([[Major Histocompatability Complexes|Major Histocompatibility Complex]]) Class I and II expression on all cells, so if they are infected, the immune system can recognise the infection and take further steps of limiting viral replication. An example is the lysis of the infected cell by [[T cells|cytotoxic T lymphocytes]], or the induction of apoptosis by [[Natural Killer cells|Natural Killer Cells]]. It is for this reason, as well as being a chemoattractant and causing the further release of other cytokines, that interferon is a potent initiator of the immune response.
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* Interferons are small polypeptides produced mainly by virus-infected cells
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** Interact with uninfected cells and render them resistant to infection
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*** This resistance is mainly due to the production of enzymes that digest viral nucleic acids
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{{Robert J Francis
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<br><br>
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|date = May 10, 2012}}
 
 
{{Jim Bee 2007}}
 
{{Jim Bee 2007}}
 
[[Category:Innate Immune System|B]]
 
[[Category:Innate Immune System|B]]
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[[Category:Robert J Francis reviewed]]
 

Revision as of 16:15, 16 March 2012

Lysozyme

  • Lysozyme is one of the major bactericidal agents in secretions
  • Helps to protect vulnerable sites such as the eyes and nasal passages
  • Exerts bactericidal effects by digesting bacterial cell walls
    • Gram-positive bacteria are more sensitive to lysozyme action than gram-negative bacteria
    • The outer membrane of gram-negative bacteria helps to protect them

Complement

  • The Complement system is a group of about 30 proteins within the body fluids of all vertebrates and some invertebrates
  • Complement promotes phagocytosis or causes lysis of an invading organism
  • Complement acts as a cascade, like the blood clotting system
    • The early enzymes in the cascade are bound to invading bacteria and fungi
      • They have an affinity for components of microbial cell membranes
    • This binding initiates a cascade so that the binding of one molecule will eventually lead to the fixation of millions of later molecules
  • The early components act as targets for phagocytes
  • The later components punch holes in bacteria, causing their lysis

Interferons

  • Lysozyme and complement have only marginal effects on virus infections because these are intracellular
    • The body has evolved non-specific mechanisms to protect against viruses
      • The most notable of these is the interferons
  • Interferons are small polypeptides produced mainly by virus-infected cells
    • Interact with uninfected cells and render them resistant to infection
      • This resistance is mainly due to the production of enzymes that digest viral nucleic acids



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