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{{review}}
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==Introduction==
 
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=Immune Tolerance=
   
Immunological tolerance occurs when there is unresponsiveness towards particular antigens, so any further immune responses are prevented or suppressed. Tolerance is required to prevent:
 
Immunological tolerance occurs when there is unresponsiveness towards particular antigens, so any further immune responses are prevented or suppressed. Tolerance is required to prevent:
 
* Potentially harmful inflammatory responses towards innocuous substances, such as air-borne or food molecules
 
* Potentially harmful inflammatory responses towards innocuous substances, such as air-borne or food molecules
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Regulatory T cells are unique in their use of a transcription repressor known as FoxP3 which is encoded by a gene on the X chromosome; rare deficiencies in FoxP3 are characterised by autoimmunity, primarily towards gut tissue, the thyroid, pancreative beta-cells and the skin. Sufferers are unable to produce regulatory T cells and the only known treatment is a bone marrow transplant from a MHC-identical sibling.
 
Regulatory T cells are unique in their use of a transcription repressor known as FoxP3 which is encoded by a gene on the X chromosome; rare deficiencies in FoxP3 are characterised by autoimmunity, primarily towards gut tissue, the thyroid, pancreative beta-cells and the skin. Sufferers are unable to produce regulatory T cells and the only known treatment is a bone marrow transplant from a MHC-identical sibling.
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==Test yourself with the Immunology Flashcards==
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{{Learning
[[Immune tolerance flashcards - Wikiblood|Immune tolerance flashcards]]
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|flashcards = [[Immune tolerance flashcards - Wikiblood|Immune tolerance flashcards]]
 
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|literature search =[http://www.cabdirect.org/search.html?q=title:(%22immune+tolerance%22)+OR+title:(%22t+cell+tolerance%22)+OR+title:(%22mucosal+tolerance%22)&fq=sc:%22ve%22 Immune Tolerance publications]
==Literature Search==
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[[File:CABI logo.jpg|left|90px]]
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Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
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<br><br><br>
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[http://www.cabdirect.org/search.html?q=title:(%22immune+tolerance%22)+OR+title:(%22t+cell+tolerance%22)+OR+title:(%22mucosal+tolerance%22)&fq=sc:%22ve%22 Immune Tolerance publications]
      
[http://www.cabdirect.org/search.html?q=title:(%22regulatory+t+cells%22)&fq=sc:%22ve%22 Regulatory T-cell publications]
 
[http://www.cabdirect.org/search.html?q=title:(%22regulatory+t+cells%22)&fq=sc:%22ve%22 Regulatory T-cell publications]
 
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}}
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<br><br>
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{{Jim Bee 2007}}
 
[[Category:Immunology]]
 
[[Category:Immunology]]
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