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[[Image:LH IgD.png|thumb|250px|right|'''IgD''']]

[[Image:LH IgD.png|thumb|150px|right|'''IgD''']]

[[Image:IgD.jpg|thumb|right|250px|IgD - B. Catchpole, RVC 2008]]

[[Image:IgD.jpg|thumb|right|150px|IgD - B. Catchpole, RVC 2008]]

<p>IgD is present in ruminants, pigs, (dogs) and rodents but has not been identified in horses, cats, rabbits and chickens.  It is mainly expressed on the surface of B-cells i.e. it is never secreted.</p>

 

IgD is present in ruminants, pigs, dogs and rodents but has not been identified in horses, cats, rabbits and chickens.  It is mainly expressed on the surface of B-cells i.e. it is never secreted.

 

==Structure==

==Structure==

<p>IgD is Y-shaped and in rodents it has two heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds.</p>

 

IgD is Y-shaped. In rodents, it has two δ heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds.

 

==Function==

==Function==

 

*IgD is only expressed in association with IgM

IgD is only expressed in association with [[IgM]]. It is thought to be important in B-cell development, although it has been shown in δ chain knockout mice (so they have no functional IgD) do not have any noticeable defects in immune function.

*It is important in B-cell development. </p>

<p> Interestingly IgD serum levels increase in allergic reactions, although it is not known why this is.</p>

 

<center><b>^{[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E - WikiBlood|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M - WikiBlood|Immunoglobulin M]]}</b></center>

 

[[Immunoglobulins|Immunoglobulins]]

 

[[Immunoglobulin A|Immunoglobulin A]]

 

[[Immunoglobulin E|Immunoglobulin E]]

 

[[Immunoglobulin G|Immunoglobulin G]]  

 

[[Immunoglobulin M|Immunoglobulin M]]

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