Difference between revisions of "B cells"
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[[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|250px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]] | [[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|250px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]] | ||
| − | Also known as '''''B lymphocytes | + | Also known as '''''B lymphocytes''''' |
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| + | So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies and are associated with '''humoral immunity''' (T cells are part of the cell-mediated immune response), and are an integral part of the [[:Category:Adaptive Immune System|'''adaptive immune system''']]. They represent 20-30% of circulating lymphocytes. | ||
| − | B cells have cell surface proteins known as B cell receptors (BCRs) that are known as immunoglobulins; [[IgM]] is the membrane bound BCR that is expressed when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24. | + | B cells have cell surface proteins known as B cell receptors (BCRs) that are known as [[Immunoglobulins - Overview|immunoglobulins]]; [[IgM]] is the membrane bound BCR that is expressed when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24. |
<p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p> | <p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p> | ||
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[[Category:Lymphocytes|B]] | [[Category:Lymphocytes|B]] | ||
Latest revision as of 16:58, 2 July 2012
Also known as B lymphocytes
So named as they were initially found in the Bursa of Fabricius, B cells produce antibodies and are associated with humoral immunity (T cells are part of the cell-mediated immune response), and are an integral part of the adaptive immune system. They represent 20-30% of circulating lymphocytes.
B cells have cell surface proteins known as B cell receptors (BCRs) that are known as immunoglobulins; IgM is the membrane bound BCR that is expressed when the B cell is immature, changing to IgD when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.
Under antigenic stimulation B cells differentiate into plasma cells and memory cells.
B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T cells on MHC II.
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Originally funded by the RVC Jim Bee Award 2007 |
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