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**Depolarisation causes calcium signalling, which stimulates insulin to be released.
 
**Depolarisation causes calcium signalling, which stimulates insulin to be released.
 
*Pre-formed granules of insulin are release initially, but this supply soon diminishes. This produces a decrease in plasma insulin levels. Insulin levels are restored as de novo insulin is synthesised and secreted.
 
*Pre-formed granules of insulin are release initially, but this supply soon diminishes. This produces a decrease in plasma insulin levels. Insulin levels are restored as de novo insulin is synthesised and secreted.
*Insulin exerts it's anabolic effect on adipocytes and skeletal muscle.
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*Insulin exerts it's anabolic effect on the liver, adipocytes and skeletal muscle.
 
**It binds to receptors on the cell membrane, which triggers an intracellular signalling cascade.
 
**It binds to receptors on the cell membrane, which triggers an intracellular signalling cascade.
 
**This causes preformed granules containing GLUT 4 receptors to be transported and expressed at the cell membrane.
 
**This causes preformed granules containing GLUT 4 receptors to be transported and expressed at the cell membrane.
 
**Cells can now take up glucose from the blood and store it as glycogen or fat.
 
**Cells can now take up glucose from the blood and store it as glycogen or fat.
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*Increased glucose levels inside the cell increases the rate of glyogenesis and an increase in the rate of production of triacylglycerides.
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*There is an increase in basal metabolic rate in other tissues.
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*Insulin regulates the
    
==Vasculature==
 
==Vasculature==
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