Difference between revisions of "Joint Response to Injury"
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| + | {{toplink | ||
| + | |backcolour =CDE472 | ||
| + | |linkpage =Musculoskeletal System - Pathology | ||
| + | |linktext =Musculoskeletal System | ||
| + | |maplink = Musculoskeletal System (Content Map) - Pathology | ||
| + | |pagetype =Pathology | ||
| + | |sublink1=Joints - Pathology | ||
| + | |subtext1=JOINTS | ||
| + | }} | ||
| + | <br> | ||
===Causes of injury === | ===Causes of injury === | ||
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===Reaction to injury=== | ===Reaction to injury=== | ||
| − | *[[Joints - | + | *[[Joints - normal#Articular cartilage|Articular cartilage]] has limited ability to regenerate |
**Superficial defects are long standing | **Superficial defects are long standing | ||
***Chondrocyte hyperplasia is ineffective at filling the defect | ***Chondrocyte hyperplasia is ineffective at filling the defect | ||
***Non-painful | ***Non-painful | ||
**Defects reaching subchondral bone | **Defects reaching subchondral bone | ||
| − | ***Filled with vascular fibroous tissue undergoing [[Cell Growth | + | ***Filled with vascular fibroous tissue undergoing [[General Pathology - Disorders of Cell Growth#Metaplasia|metaplasia]] into cartilage |
***Painful | ***Painful | ||
**Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface | **Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface | ||
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*Synovial membranes respond by: | *Synovial membranes respond by: | ||
**Villous hypertrophy | **Villous hypertrophy | ||
| − | ***+/- synovitis | + | ***+/- [[Joints Inflammatory - Pathology|synovitis]] |
**Hyperplasia | **Hyperplasia | ||
| − | |||
| − | |||
| − | |||
Revision as of 19:52, 18 August 2008
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Causes of injury
- Trauma
- Instability
- Lubrication failure
- Infectious organisms
- Immune-mediated disease
Reaction to injury
- Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
- Chondrocyte hyperplasia is ineffective at filling the defect
- Non-painful
- Defects reaching subchondral bone
- Filled with vascular fibroous tissue undergoing metaplasia into cartilage
- Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
- Superficial defects are long standing
- Synovial membranes respond by:
- Villous hypertrophy
- +/- synovitis
- Hyperplasia
- Villous hypertrophy